ACID AEROSOL EXPOSURE: ASSESSMENT AND HEALTH EFFECTS

这项研究将继续我们的调查的影响，酸 气溶胶空气污染暴露对人体健康的影响。 多年来， 环境空气酸性气溶胶、共同污染物和气象数据现在 作为一种可供北美各地社区使用的 由于纽约大学和哈佛大学最近的表现， 污染暴露/健康影响评估研究。 整体 因此，这项持续研究的目标将是采用新的 我们所获得的关于酸的性质和发生的知识 环境中的气溶胶，以进行更广泛的 酸性气溶胶影响的回顾性流行病学评估 对人体健康的影响。 我们建议分两个阶段进行这项研究：1）建立 回顾性估计人群照射的经验方法 酸性气溶胶; 2）这些暴露评估的应用 现有的大规模流行病学数据库的方法。 我们将使用 新的可用酸性气溶胶暴露数据，以建立可推广的 用于估计过去人群酸性气溶胶暴露的方法和模型。 这将允许将模拟的酸性气溶胶暴露与 已经存在的大的，质量有保证的健康结果数据集， 一系列回顾性流行病学调查， 酸性气溶胶对人体健康的影响。 这些数据库将包括 NHANES II肺功能测定的全国横断面记录， 发病率从HIS，死亡率从美国人口普查， 以及1974-1983年加拿大安大略医院入院数据， 贝茨和西斯托 这些统计调查， 酸性气溶胶可能对健康产生的影响将解决混淆问题 环境因素和潜在贡献和/或相互作用 其他空气污染物。 因此，除了扩展方法之外， 可用于回顾性人体暴露评估，本研究将 扩大区域和健康结果的范围， 可以评估酸性气溶胶的影响。

This research will continue our investigation of the effects of acid aerosol air pollution exposures on human health. Numerous site-years of ambient air acid aerosol, co-pollutant, and meteorological data have now become available for a variety of communities throughout North America as a result of the recent performance of the NYU and Harvard University air pollution exposure/health effects assessment studies. The overall objective of this continuing research will, therefore, be to employ the new knowledge we have gained regarding the nature and occurrence of acid aerosols in the environment in order to conduct a wider range of retrospective epidemiologic assessments of the impacts of acid aerosol exposures on human health. We propose to conduct this research in two phases: 1) the establishment of empirical methods for the retrospective estimation of population exposures to acid aerosols; and 2) the application of these exposure assessment methods to existing large scale epidemiologic data bases. We will use the newly available acid aerosol exposure data to establish generalizable methods and models for estimating past population acid aerosol exposures. This will then allow the merging of modeled acid aerosol exposures with already existing large, quality-assured health outcome data sets for a wide range of retrospective epidemiological investigations into the potential human health effects of acid aerosols. These data bases will include the nationwide cross-sectional records for spirometry from NHANES II, for morbidity from the HIS, and for mortality rates from the U.S. Census, as well as the 1974-1983 Ontario, Canada hospital admissions data compiled by Bates and Sizto. These statistical investigations into the various possible health effects of acid aerosols will address confounding environmental factors and potential contributions by and/or interactions with other air pollutants. Thus, in addition to expanding the methods available for retrospective human exposure assessment, this research will broaden the scope of both locations and health outcomes for which the effects of acid aerosols can be assessed.