MOLECULAR MECHANISMS OF POLLUTANT WITH RED CELLS

红细胞污染物的分子机制

• 批准号: 3252324
• 负责人: JOSEPH BONAVENTURA
• 金额: $ 14.63万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3252324
• 关键词: NAD(H) phosphate; X ray crystallography; aniline; aniline dye; aquatic biology; cytochromes; electron transport; erythrocytes; free radicals; hemoglobin; hemoprotein structure; human tissue; lipid peroxides; metal poisoning; methemoglobin; myoglobin; occupational hazard; oxygenases; oxyhemoglobin; pollutant interaction; porphyrin structure; respiratory oxygenation; saltwater environment; spectrometry; stoichiometry; superoxides; water pollution

The Duke University Marine Biomedical Center promotes and integrates multidisciplinary research on aquatic organisms with a focus on environmental health problems. Ongoing programs of the Center illustrate how the great diversity among marine organisms can be used to an advantage in sorting out the fundamental mechanisms which underlie molecular, cellular and organismic behavior in normal and pathological states. Continued support for the Duke University Marine Biomedical Center is requested to allow for further productive interactions between established investigators having experience in various aspects of medical and marine sciences. The Administrative Core Unit of the Marine Biomedical Center stimulates research and information exchange concerning problems in the marine sciences that are related to environmental health. Strong ties with the Duke University Medical Center facilitate the transfer of research findings of the Center to the medical community. The Administrative Unit also coordinates lectures, meetings, a Visiting Scholar Program and publishes a bimonthly newsletter, ENVIRONS. The Facilities and Services Unit makes available to participants and associates of the Center a number of laboratory services and special equipment items capable of analyzing pollutant concentrations and effects. The participants in the Research Unit of the Center make use of marine organisms in studies which have high potential for clarification of fundamental processes which may be sensitive to environmental stress. Ongoing programs include studies concerning: 1) the effects of chemical pollutants on respiratory proteins and electron transport proteins, 2) the effects of metal and non-metal pollutants on larval development of various invertebrates, 3) pollutant toxicology using blood as a model organ, 4) behavioral aspects of pollution in estuarine and marine systems, 5) the effect of metal and non-metal pollutants on transport processes, 6) pollutant effects on gene activation and embryological development, and 7) mechanisms of trace metal detoxification in marine organisms. The Research Unit funds feasibility studies to extend and integrate these ongoing research programs.

杜克大学海洋生物医学中心促进和整合 水生生物的多学科研究，重点是 环境健康问题。 该中心正在进行的计划表明 如何利用海洋生物的巨大多样性来发挥优势 在理清分子基础的基本机制时， 正常和病理状态下的细胞和有机体行为。 对杜克大学海洋生物医学中心的持续支持是 要求允许已建立的机构之间进行进一步富有成效的互动 具有医学和海洋各个方面经验的研究人员 科学。 海洋生物医学中心行政核心单位 促进有关问题的研究和信息交流 与环境健康相关的海洋科学。 与 密切联​​系 杜克大学医学中心促进研究成果转移 该中心向医学界报告研究结果。 行政单位 还协调讲座、会议、访问学者计划和 出版双月刊时事通讯《ENVIRONS》。 设施和服务 该单位向中心的参与者和同事提供了一些 能够分析的实验室服务和特殊设备项目 污染物浓度和影响。 研究参与者 该中心的单位利用海洋生物进行研究，具有很高的 澄清可能敏感的基本过程的潜力 环境压力。 正在进行的项目包括以下方面的研究：1) 化学污染物对呼吸蛋白和电子的影响 转运蛋白，2）金属和非金属污染物对 各种无脊椎动物的幼虫发育，3) 污染物毒理学利用 血液作为模型器官，4）河口污染的行为方面 海洋系统，5）金属和非金属污染物对海洋系统的影响 运输过程，6) 污染物对基因激活的影响和 胚胎发育，7) 微量金属解毒机制 在海洋生物中。 研究单位资助可行性研究以扩展 并整合这些正在进行的研究项目。