MARINE/FRESHWATER BIOMEDICAL CENTER GRANT

海洋/淡水生物医学中心拨款

• 批准号: 3102303
• 负责人: JOSEPH BONAVENTURA
• 金额: $ 18.72万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-08-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3102303
• 关键词: environmental health; environmental toxicology; fresh water environment; saltwater environment

The Duke University Marine Biomedical Center promotes and integrates multidisciplinary research on aquatic organisms with a focus on environmental health problems. Ongoing programs of the Center illustrate how the great diversity among marine organisms can be used to an advantage in sorting out the fundamental mechanisms which underlie molecular, cellular and organismic behavior in normal and pathological states. Continued support for the Duke University Marine Biomedical Center is requested to allow for further productive interactions between established investigators having experience in various aspects of medical and marine sciences. The Administrative Core Unit of the Marine Biomedical Center stimulates research and information exchange concerning problems in the marine sciences that are related to environmental health. Strong ties with the Duke University Medical Center facilitate the transfer of research findings of the Center to the medical community. The Administrative Unit also coordinates lectures, meetings, a Visiting Scholar Program and publishes a bimonthly newsletter, ENVIRONS. The Facilities and Services Unit makes available to participants and associates of the Center a number of laboratory services and special equipment items capable of analyzing pollutant concentrations and effects. The participants in the Research Unit of the Center make use of marine organisms in studies which have high potential for clarification of fundamental processes which may be sensitive to environmental stress. Ongoing programs include studies concerning: 1) the effects of chemical pollutants on respiratory proteins and electron transport proteins, 2) the effects of metal and non-metal pollutants on larval development of various invertebrates, 3) pollutant toxicology using blood as a model organ, 4) behavioral aspects of pollution in estuarine and marine systems, 5) the effect of metal and non-metal pollutants on transport processes, 6) pollutant effects on gene activation and embryological development, and 7) mechanisms of trace metal detoxification in marine organisms. The Research Unit funds feasibility studies to extend and integrate these ongoing research programs.

杜克大学海洋生物医学中心促进和整合 水生生物的多学科研究，重点是 环境健康问题。 该中心正在进行的方案说明， 如何利用海洋生物的巨大多样性 在梳理分子的基本机制时， 正常和病理状态下的细胞和器官行为。 继续支持杜克大学海洋生物医学中心， 请秘书长允许常设机构之间进一步进行富有成效的互动， 调查人员在医疗和海事的各个方面都有经验 以理工科为重 海洋生物医学中心行政核心单位 鼓励就联合国系统内的问题进行研究和信息交流， 与环境健康有关的海洋科学。 联系紧密， 杜克大学医学中心促进了研究成果的转移 该中心向医学界提供的调查结果。 行政股 还协调讲座，会议，访问学者计划， 出版双月通讯《新闻》。 一流设施和优质服务 该股向中心的参与者和同事提供了一个数字， 实验室服务和能够分析的特殊设备项目 污染物浓度和影响。 研究的参与者 该中心的单位利用海洋生物的研究，具有很高的 澄清可能敏感的基本过程的潜力 to environmental环境stress应力. 正在进行的方案包括以下方面的研究： 化学污染物对呼吸蛋白和电子的影响 运输蛋白质，2）金属和非金属污染物对 各种无脊椎动物的幼虫发育，3）污染物毒理学， 血液作为模式器官，4）河口污染的行为方面， 海洋系统，5）金属和非金属污染物对 运输过程，6）污染物对基因激活的影响， 胚胎发育; 7）微量金属解毒机制 in marine海洋organisms生物. 研究组资助可行性研究， 并整合这些正在进行的研究项目。