SUPERIOR COLLICULUS--DEVELOPMENT OF VISUAL PROPERTIES

上丘——视觉特性的发展

• 批准号: 3262866
• 负责人: BARRY E STEIN
• 金额: $ 8.68万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262866
• 关键词: afferent nerve; cats; developmental neurobiology; evolution; histochemistry /cytochemistry; neuroanatomy; neurophysiology; neuropsychology; neurotransmitters; newborn animals; superior colliculus; visual cortex; visual fields; visual pathways

That the superior colliculus is intimately involved in visually-guided behaviors has been known for some time. Because the maturation of the superior colliculus is a protracted postnatal event, it offers a unique opportunity for correlating anatomical and physiological data directly with the chronology of visuomotor behaviors. Since the receptive field properties of its cells serve as selective 'gates' to the circuitry of the superior colliculus and thereby determine which stimuli elicit visually-guided behavior, a host of studies of these properties have been conducted in developing animals. Because visual cells are concentrated most heavily in the superficial laminae of the structure, this is the population that has been examined most closely. More recent information indicates, however, that these are not the cells most directly involved in visually-guided behaviors. Rather, it is the deeper laminae cells, whose axons project to motor and premotor areas, that are most relevant. These cells receive different visual afferents than do superficial laminae cells and may show substantially different ontogenetic time courses and have different developmental requirements that reflect their differing behavioral roles. Unfortunately, we know very little about the maturation of deep laminae cells or the development of the corticotectal afferents that determine their complex receptive field properties. In the next 5 years we will employ a multidisciplinary approach that will not only document the maturation of deep laminae receptive field properties but will also determine the maturation of corticotectal afferents (from lateral suprasylvian cortex) and the behaviors dependent on these afferents. We will employ anatomical, behavioral, histochemical, and physiological techniques in an effort to produce a comprehensive evaluation of the maturation of deep laminae visual cells, and thereby begin realizing some of the objectives that originally prompted much of the interest in the development of the superior colliculus.

上丘与视觉引导密切相关 行为已为人所知有一段时间了。 因为成熟的 上丘是一种旷日持久的产后事件，它提供了独特的 直接关联解剖学和生理学数据的机会 与视觉运动行为的时间顺序。 由于感受野 其细胞的特性充当电路的选择性“门” 上丘，从而确定引起哪些刺激 视觉引导的行为，对这些特性的大量研究已经 已在发育中的动物身上进行。 因为视觉细胞是 最集中在结构的浅层， 这是经过最仔细检查的人群。 最近的 然而，信息表明，这些并不是最重要的细胞。 直接参与视觉引导的行为。 相反，它是 更深的层细胞，其轴突投射到运动和前运动区域， 最相关的。 这些细胞接收不同的视觉传入 与浅层细胞相比，可能表现出本质上的不同 个体发生时间进程和有不同的发育要求 反映了他们不同的行为角色。 不幸的是，我们知道 关于深层细胞的成熟或 决定其复杂性的皮质传入神经的发育 感受野属性。 未来 5 年，我们将采用多学科方法 不仅会记录深层感受野的成熟 特性，但也决定了皮质顶盖的成熟 传入神经（来自外侧外侧上皮质）和依赖行为 在这些传入上。 我们将采用解剖学、行为学、 组织化学和生理学技术，努力产生 综合评估深层视觉细胞的成熟度， 从而开始实现一些最初的目标 引起了人们对上级发展的极大兴趣 丘。