AN ANIMAL MODEL FOR THE DEVELOPMENT OF MYOPIA

近视发展的动物模型

• 批准号: 3259210
• 负责人: WILLIAM HODOS
• 金额: $ 5.43万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3259210
• 关键词: contact lens; disease /disorder model; eye accommodation; model design /development; myopia; neural information processing; retina; vision tests; visual feedback; visual stimulus

The purpose of the proposed research is to develop a model of myopia that could be used to evaluate treatment techniques for ultimate application to humans. Our preliminary experiments have indicated that defocus of the retinal image in domestic chicks for the first three weeks of life results in an increase in the diameter of the globe of the eye that is suggestive of myopia. The specific aims of the proposed research are to replicate our preliminary findings using more precisely defined optical devices and then to use behavioral techniques to assess the degree of myopia. The myopia will be calculated from a comparison of the far point of accommodation in treated and untreated chicks. Visual acuity and intensity difference thresholds will be determined in order to assess whether the defocussing procedure has produced impairments of visual information processing either in the retina or centrally. If myopia is present in the chicks, an attempt will be made to correct the defect by interposing an optometric trial lens between the cornea and the target. Finally, an attempt will be made to evaluate the hypothesis that a cause of myopia is intensive and prolonged inspection of the spatial properties of visual stimuli close to the near point of accommodation by comparing the eyes of untreated subjects in visual acuity tests with the eyes of another group of chicks that have had equivalent experience with a test of comparable difficulty, but in which the spatial properties of the stimulus are irrelevant. The advantages of such a model are (1) very low expense, (2) very rapid development and (3) suitability for the evaluation of mechanical and surgical treatments for myopia, such as orthokeratosis, radial keratotomy, keratomileusis, hydrogel lenticular implantation, etc.

这项研究的目的是开发一种近视模型， 可用于评估最终应用于 人类 我们的初步实验表明， 国产雏鸡出生后前三周的视网膜图像结果 眼睛的地球仪直径的增加表明 近视。 拟议研究的具体目标是复制我们的 使用更精确定义的光学设备的初步研究结果， 使用行为技术来评估近视的程度。 近视 将通过比较远点的住宿计算， 处理和未处理的小鸡。 视敏度和强度差 将确定阈值，以评估散焦是否 程序已经产生了视觉信息处理的障碍， 在视网膜或中央。 如果小鸡出现近视， 将通过插入验光试透镜来纠正缺陷 在角膜和目标之间。 最后，将尝试 评估近视的原因是密集和长期的假设， 近距离视觉刺激的空间特性检查 通过比较未治疗受试者的眼睛， 用另一组小鸡的眼睛进行视力测试， 具有相当难度的测试，但其中 刺激的空间属性是无关紧要的。 的优点 这种模式是（1）非常低费用，（2）非常快速的发展，以及（3） 机械和手术治疗评价的适用性 近视，如角膜矫正术、放射状角膜切开术、角膜磨镶术、水凝胶 晶状体植入等。