OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
基本信息
- 批准号:3258460
- 负责人:
- 金额:$ 19.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1982
- 资助国家:美国
- 起止时间:1982-03-01 至 1990-02-28
- 项目状态:已结题
- 来源:
- 关键词:active immunization antiinflammatory agents cellular immunity chemoattractants conjunctivitis disease /disorder model electron microscopy eosinophil helminthic antigen histopathology humoral immunity immunoglobulin E immunoglobulin G immunologic techniques immunopathology inflammation keratitis microscopy monoclonal antibody parasitic eye infections passive immunization retina degeneration retinal pigment epithelium tissue /cell culture
项目摘要
The roles of different immunopathologic mechanisms in diseases of the eye
are incompletely understood. Distinct local and/or systemic cellular and
humoral mechanisms may have significantly different roles, either alone or
in concert with other mechanisms, in causing ocular inflammation and damage
to vital ocular structures and in controlling infectious agents in the
eye. An understanding of the separate and collective roles of the
different immunopathologic mechanisms in ocular inflammatory disease would
be of great value towards the ultimate goal of separating protective from
damaging effects of immune responses in the eye. Such responses are the
cause of a substantial proportion of blindness world-wide. The present
studies will concentrate on the interactions of immunopathologic mechanisms
mediated by homocytotropic (e.g., IgE) antibodies, eosinophils and mast
cells in four models of ocular allergy: 1) Experimental vernal
conjunctivitis produced in guinea pigs by topical application of
fluoresceinylovalbumin or ascarid antigens; 2) Experimental ocular
onchocerciasis produced in guinea pigs by the injection of Onchocerca
microfilariae; 3) Spontaneous hypersensitivity to environmental antigens in
the atopic dog; 4) Retinal pigment epitheliopathy and retinal degeneration
associated with an eosinophil choroiditis in ascarid-infected eyes. The
effects of immunological manipulations (e.g. variations in route, timing
and dosage of antigens, concomitant sensitization with other antigens,
selective anti-inflammatory drugs) on the development of lesions in the
vernal conjunctivitis model will be defined in detail. Local antibody
production will be studied in cultures of conjunctival lymphoid cells. The
roles of specific mediators (e.g. eosinophil chemotactic factors,
eosinophil and mast cell constituents) in the vernal model, and in the
retinal pigment epitheliopathy of ascarid-infected eyes, will be studied in
vivo by application of injection of mediators to or into the eye, and in
vitro by employing cultures of conjunctival, corneal, and retinal pigmented
epithelial cells. The ability of anti-inflammatory drugs and immunological
manipulations to affect the acute corneal inflammation caused by
diethylcarbazamine citrate treatment of experimental ocular onchocerciasis
in guinea pigs will be defined in detail.
不同免疫病理机制在眼部疾病中的作用
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN ROCKEY其他文献
JOHN ROCKEY的其他文献
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{{ truncateString('JOHN ROCKEY', 18)}}的其他基金
OCULAR MECHANISMS OF REJECTION OF CORNEAL ENDOTHELIUM
角膜内皮排斥的眼部机制
- 批准号:
3263050 - 财政年份:1986
- 资助金额:
$ 19.95万 - 项目类别:
OCULAR MECHANISMS OF REJECTION OF CORNEAL ENDOTHELIUM
角膜内皮排斥的眼部机制
- 批准号:
3263049 - 财政年份:1986
- 资助金额:
$ 19.95万 - 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
- 批准号:
3258462 - 财政年份:1982
- 资助金额:
$ 19.95万 - 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
- 批准号:
3258461 - 财政年份:1982
- 资助金额:
$ 19.95万 - 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
- 批准号:
3258456 - 财政年份:1982
- 资助金额:
$ 19.95万 - 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
- 批准号:
3258463 - 财政年份:1982
- 资助金额:
$ 19.95万 - 项目类别:
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