OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE

眼部炎症性疾病的眼部机制

基本信息

  • 批准号:
    3258460
  • 负责人:
  • 金额:
    $ 19.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1982
  • 资助国家:
    美国
  • 起止时间:
    1982-03-01 至 1990-02-28
  • 项目状态:
    已结题

项目摘要

The roles of different immunopathologic mechanisms in diseases of the eye are incompletely understood. Distinct local and/or systemic cellular and humoral mechanisms may have significantly different roles, either alone or in concert with other mechanisms, in causing ocular inflammation and damage to vital ocular structures and in controlling infectious agents in the eye. An understanding of the separate and collective roles of the different immunopathologic mechanisms in ocular inflammatory disease would be of great value towards the ultimate goal of separating protective from damaging effects of immune responses in the eye. Such responses are the cause of a substantial proportion of blindness world-wide. The present studies will concentrate on the interactions of immunopathologic mechanisms mediated by homocytotropic (e.g., IgE) antibodies, eosinophils and mast cells in four models of ocular allergy: 1) Experimental vernal conjunctivitis produced in guinea pigs by topical application of fluoresceinylovalbumin or ascarid antigens; 2) Experimental ocular onchocerciasis produced in guinea pigs by the injection of Onchocerca microfilariae; 3) Spontaneous hypersensitivity to environmental antigens in the atopic dog; 4) Retinal pigment epitheliopathy and retinal degeneration associated with an eosinophil choroiditis in ascarid-infected eyes. The effects of immunological manipulations (e.g. variations in route, timing and dosage of antigens, concomitant sensitization with other antigens, selective anti-inflammatory drugs) on the development of lesions in the vernal conjunctivitis model will be defined in detail. Local antibody production will be studied in cultures of conjunctival lymphoid cells. The roles of specific mediators (e.g. eosinophil chemotactic factors, eosinophil and mast cell constituents) in the vernal model, and in the retinal pigment epitheliopathy of ascarid-infected eyes, will be studied in vivo by application of injection of mediators to or into the eye, and in vitro by employing cultures of conjunctival, corneal, and retinal pigmented epithelial cells. The ability of anti-inflammatory drugs and immunological manipulations to affect the acute corneal inflammation caused by diethylcarbazamine citrate treatment of experimental ocular onchocerciasis in guinea pigs will be defined in detail.
不同免疫病理机制在眼部疾病中的作用

项目成果

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JOHN ROCKEY其他文献

JOHN ROCKEY的其他文献

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{{ truncateString('JOHN ROCKEY', 18)}}的其他基金

SPECTROPHOTOMETER
分光光度计
  • 批准号:
    3524460
  • 财政年份:
    1989
  • 资助金额:
    $ 19.95万
  • 项目类别:
LIQUID SCINTILLATION COUNTER
液体闪烁计数器
  • 批准号:
    3524376
  • 财政年份:
    1987
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF REJECTION OF CORNEAL ENDOTHELIUM
角膜内皮排斥的眼部机制
  • 批准号:
    3263050
  • 财政年份:
    1986
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF REJECTION OF CORNEAL ENDOTHELIUM
角膜内皮排斥的眼部机制
  • 批准号:
    3263049
  • 财政年份:
    1986
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
  • 批准号:
    3258462
  • 财政年份:
    1982
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
  • 批准号:
    3258461
  • 财政年份:
    1982
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
  • 批准号:
    3258456
  • 财政年份:
    1982
  • 资助金额:
    $ 19.95万
  • 项目类别:
OCULAR MECHANISMS OF INFLAMMATORY DISEASES OF THE EYE
眼部炎症性疾病的眼部机制
  • 批准号:
    3258463
  • 财政年份:
    1982
  • 资助金额:
    $ 19.95万
  • 项目类别:

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  • 批准号:
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  • 财政年份:
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非甾体抗炎药对甲状腺激素水平的影响
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  • 财政年份:
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CARIBBEAN CORALS (PSEUDOPTEROGORIA) AS SOURCE OF NEW ANTIINFLAMMATORY AGENTS)
加勒比珊瑚(PSEUDOPTEROGORIA)作为新型抗炎剂的来源)
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    6107139
  • 财政年份:
    1998
  • 资助金额:
    $ 19.95万
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