Development of a Nucleoside Diphosphate Platform for the Chemo-Enzymatic Synthesis of Nucleoside Triphosphates

开发用于化学酶合成核苷三磷酸的核苷二磷酸平台

• 批准号: BB/T004134/1
• 负责人: David Hodgson
• 金额: $ 25.71万
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT004134%2F1
• 关键词: Development; Nucleoside; Diphosphate; Platform; Chemo

Nucleoside triphosphates (NTPs) are Nature's raw materials for the assembly of the nucleic acids that store genetic material. We have developed an enzyme-based method that allows us to prepare NTPs. We use inexpensive materials in our processes, however, we are not sure how efficient or broadly-applicable our system is or how it compares to other known enzyme systems. We have gathered independent market research to show that our system could have broad interest to industrialists. Through this consultation, however, it was clear that further information on the breadth of scope and the limitations of our system were required before industry could consider adopting it. Furthermore, we also need to convert our system from something that works in a research laboratory into something that can be employed robustly on a chemical plant. The proposed work aims to broaden our understanding and translate our research towards industrial applications

核苷三磷酸（NTPs）是自然界的原材料，用于组装储存遗传物质的核酸。我们开发了一种基于酶的方法，使我们能够制备NTPs。我们在我们的过程中使用廉价的材料，但是，我们不确定我们的系统有多有效或广泛适用，或者与其他已知的酶系统相比如何。我们收集了独立的市场研究，表明我们的制度可能会引起工业家的广泛兴趣。然而，通过这次咨询，很明显，在工业界考虑采用我们的系统之前，需要进一步了解我们的系统的范围和局限性。此外，我们还需要将我们的系统从研究实验室的系统转换为可以在化工厂可靠使用的系统。拟议的工作旨在扩大我们的理解，并将我们的研究转化为工业应用