AAFC IWYP Aligned Call; Circadian clock editing in wheat
AAFC IWYP Aligned Call; Circadian clock editing in wheat
批准号:
BB/T004282/1
负责人:
Ian Henderson
金额:
$25.28万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2019
资助国家:
英国
项目状态:
未结题
起止时间:
2019 至 --
中文摘要
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英文摘要
The overall aim of this project is to utilize advanced biotechnology, genomics, functional genomics, and breeding techniques to develop next-generation wheat germplasm that will increase the security of global wheat production and address the need for a 50% increase in genetic yield potential by 2050 (IWYP). Global warming is predicted to increase temperature and the frequency of extreme weather events, and also to alter precipitation patterns and abundance, thus changing water availability to crops. Another direct consequence is that the number of frost-free days in many regions will become comparable to what is typical of more southern regions, however the day length will remain unchanged. For this reason, alignment of photoperiodic requirements with the growing season is key to the successful integration of high yielding wheat genotypes. It is imperative that we protect wheat production by developing next-generation germplasm that is adaptable and resilient to anticipated variable climatic conditions. This project will seek to generate and deploy genetic variation in circadian clock genes with relevance to IWYP aims of increasing yield in several ways: 1. We will harness the power of circadian clock genes in controlling yield and stress responses. 2. We will optimize growth through modulation of circadian clock genes for yield increase and improved stress responses. 3. The circadian clock mutant (ccWheat) germplasm will be incorporated into wheat breeding at AAFC and elsewhere. 4. Mutational breeding tools, genome editing and methods to control recombination, will be further developed for accelerating breeding for yield and stress responses.
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HIGH CROSSOVER RATE1 encodes PROTEIN PHOSPHATASE X1 and restricts meiotic crossovers in Arabidopsis.
DOI:
10.1038/s41477-021-00889-y
发表时间:
2021-04
期刊:
Nature plants
影响因子:
18
作者:
[Nageswaran DC, Kim J, Lambing C, Kim J, Park J, Kim EJ, Cho HS, Kim H, Byun D, Park YM, Kuo P, Lee S, Tock AJ, Zhao X, Hwang I, Choi K, Henderson IR]
通讯作者:
Henderson IR
DOI:
10.1101/gr.273672.120
发表时间:
2021-09
期刊:
Genome research
影响因子:
7
作者:
[Tock AJ, Holland DM, Jiang W, Osman K, Sanchez-Moran E, Higgins JD, Edwards KJ, Uauy C, Franklin FCH, Henderson IR]
通讯作者:
Henderson IR
DOI:
10.1073/pnas.2021970118
发表时间:
2021-08-17
期刊:
Proceedings of the National Academy of Sciences of the United States of America
影响因子:
11.1
作者:
[Zhu L, Fernández-Jiménez N, Szymanska-Lejman M, Pelé A, Underwood CJ, Serra H, Lambing C, Dluzewska J, Bieluszewski T, Pradillo M, Henderson IR, Ziolkowski PA]
通讯作者:
Ziolkowski PA
The genetic and epigenetic landscape of the Arabidopsis centromeres.
拟南芥着丝粒的遗传和表观遗传景观。
DOI:
10.17863/cam.78413
发表时间:
2021
期刊:
影响因子:
--
作者:
[Naish M]
通讯作者:
Naish M
Validation of Early Warning Systems for Severe Maternal Morbidity and Individualised Prediction of Severe Maternal Morbidity within Ethnic Groups
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批准号:MR/X006115/1
-
项目类别:Fellowship
-
资助金额:$34.9万
-
财政年份:2023
-
负责人:Ian Henderson
-
依托单位:
Assembling and recombining the Arabidopsis centromeres
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批准号:BB/V003984/1
-
项目类别:Research Grant
-
资助金额:$81.15万
-
财政年份:2021
-
负责人:Ian Henderson
-
依托单位:
18-BTT: High-throughput fluorescent crossover reporters to dissect control of tomato meiotic recombination
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批准号:BB/S020012/1
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项目类别:Research Grant
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资助金额:$25.79万
-
财政年份:2019
-
负责人:Ian Henderson
-
依托单位:
HEI10: a master switch for recombination in plants
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批准号:BB/S006842/1
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项目类别:Research Grant
-
资助金额:$78.93万
-
财政年份:2019
-
负责人:Ian Henderson
-
依托单位:
EpiSpiX - Unlocking plant genetic diversity via epi-modification & targeted recombination.
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批准号:BB/N007557/1
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项目类别:Research Grant
-
资助金额:$68.88万
-
财政年份:2016
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负责人:Ian Henderson
-
依托单位:
Pathfinder: Determining the efficacy of plasmapheresis as a treatment for patients with chronic Pseudomonas infections and inhibitory antibodies
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批准号:MR/N027027/1
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项目类别:Research Grant
-
资助金额:$90.82万
-
财政年份:2016
-
负责人:Ian Henderson
-
依托单位:
Understanding phopspholipid homeostasis in Gram-negative bacteria
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批准号:BB/M00810X/1
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项目类别:Research Grant
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资助金额:$72.12万
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财政年份:2015
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负责人:Ian Henderson
-
依托单位:
13 ERA-CAPS. Delineating the crossover control networks in plants (DeCOP)
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批准号:BB/M004937/1
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项目类别:Research Grant
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资助金额:$36.53万
-
财政年份:2014
-
负责人:Ian Henderson
-
依托单位:
MicrobesNG: A scalable replicable biological sample repository incorporating whole-genome sequence data and analysis of thousands of microbial strains
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批准号:BB/L024209/1
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项目类别:Research Grant
-
资助金额:$133.98万
-
财政年份:2014
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负责人:Ian Henderson
-
依托单位:
meiTALENs: Directing crossover recombination with meiotic TAL nucleases
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批准号:BB/L006847/1
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项目类别:Research Grant
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资助金额:$53.22万
-
财政年份:2014
-
负责人:Ian Henderson
-
依托单位:
Genome-wide mapping of recombination hotspots in Arabidopsis
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批准号:BB/K007882/1
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项目类别:Research Grant
-
资助金额:$43.27万
-
财政年份:2013
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负责人:Ian Henderson
-
依托单位:
13TSB_SynBio: Engineering immune-cell-targeting bacteria to express vaccines from within the body
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批准号:BB/L004461/1
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项目类别:Research Grant
-
资助金额:$22.32万
-
财政年份:2013
-
负责人:Ian Henderson
-
依托单位:
Selective biochemical and synthetic biology approaches for improved delivery of recombinant proteins to the extracellular milieu
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批准号:BB/I020756/1
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项目类别:Research Grant
-
资助金额:$56.59万
-
财政年份:2011
-
负责人:Ian Henderson
-
依托单位:
Collaborative Doctoral 2010 Grant - Historicising the British Museum's Australian Aboriginal and Torres Strait Islander collection.
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批准号:AH/I505423/1
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项目类别:Training Grant
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资助金额:$5.22万
-
财政年份:2010
-
负责人:Ian Henderson
-
依托单位:
Development of an integrated system for the production and delivery of recombinant biotherapeutics
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批准号:G0900857/1
-
项目类别:Research Grant
-
资助金额:$49.3万
-
财政年份:2009
-
负责人:Ian Henderson
-
依托单位:
Understanding the role of the Bam complex in the biogenesis of outer membrane proteins
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批准号:G0801209/1
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项目类别:Research Grant
-
资助金额:$52.56万
-
财政年份:2009
-
负责人:Ian Henderson
-
依托单位:
Understanding events at the cell surface during autotransporter biogenesis
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批准号:G0700151/1
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项目类别:Research Grant
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资助金额:$49.1万
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财政年份:2007
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负责人:Ian Henderson
-
依托单位:
Understanding the role of the outer membrane translocator in autotransporter biogenesis
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批准号:BB/E021174/1
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项目类别:Research Grant
-
资助金额:$48.86万
-
财政年份:2007
-
负责人:Ian Henderson
-
依托单位:
海外基金