AAFC IWYP Aligned Call; Circadian clock editing in wheat

AAFC IWYP 一致呼吁；

• 批准号: BB/T004282/1
• 负责人: Ian Henderson
• 金额: $ 25.28万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT004282%2F1
• 关键词: AAFC; IWYP; Aligned; Call; Circadian

The overall aim of this project is to utilize advanced biotechnology, genomics, functional genomics, and breeding techniques to develop next-generation wheat germplasm that will increase the security of global wheat production and address the need for a 50% increase in genetic yield potential by 2050 (IWYP). Global warming is predicted to increase temperature and the frequency of extreme weather events, and also to alter precipitation patterns and abundance, thus changing water availability to crops. Another direct consequence is that the number of frost-free days in many regions will become comparable to what is typical of more southern regions, however the day length will remain unchanged. For this reason, alignment of photoperiodic requirements with the growing season is key to the successful integration of high yielding wheat genotypes. It is imperative that we protect wheat production by developing next-generation germplasm that is adaptable and resilient to anticipated variable climatic conditions. This project will seek to generate and deploy genetic variation in circadian clock genes with relevance to IWYP aims of increasing yield in several ways: 1. We will harness the power of circadian clock genes in controlling yield and stress responses. 2. We will optimize growth through modulation of circadian clock genes for yield increase and improved stress responses. 3. The circadian clock mutant (ccWheat) germplasm will be incorporated into wheat breeding at AAFC and elsewhere. 4. Mutational breeding tools, genome editing and methods to control recombination, will be further developed for accelerating breeding for yield and stress responses.

该项目的总体目标是利用先进的生物技术、基因组学、功能基因组学和育种技术开发下一代小麦种质，以提高全球小麦生产的安全性，并解决到2050年遗传产量潜力增加50%的需求。据预测，全球变暖将使气温升高，极端天气事件发生的频率增加，并将改变降水模式和降水量，从而改变作物的供水量。另一个直接后果是，许多地区的无霜期将与南部地区的无霜期相当，但日长将保持不变。因此，光周期要求与生长季节的一致性是高产小麦基因型成功整合的关键。我们必须通过开发下一代种质来保护小麦生产，这些种质对预期的可变气候条件具有适应性和弹性。该项目将寻求在生物钟基因中产生和部署与IWYP目标相关的遗传变异，以几种方式增加产量：1。我们将利用生物钟基因的力量来控制产量和压力反应。2.我们将通过调节生物钟基因来优化生长，以提高产量和改善应激反应。3.生物钟突变体（ccWheat）种质将被纳入AAFC和其他地方的小麦育种。4.将进一步开发突变育种工具、基因组编辑和控制重组的方法，以加速产量和胁迫反应的育种。

项目成果

HIGH CROSSOVER RATE1 encodes PROTEIN PHOSPHATASE X1 and restricts meiotic crossovers in Arabidopsis.

• DOI: 10.1038/s41477-021-00889-y
• 发表时间: 2021-04
• 期刊: Nature plants
• 影响因子: 18
• 作者: Nageswaran DC;Kim J;Lambing C;Kim J;Park J;Kim EJ;Cho HS;Kim H;Byun D;Park YM;Kuo P;Lee S;Tock AJ;Zhao X;Hwang I;Choi K;Henderson IR
• 通讯作者: Henderson IR

Crossover-active regions of the wheat genome are distinguished by DMC1, the chromosome axis, H3K27me3, and signatures of adaptation.

• DOI: 10.1101/gr.273672.120
• 发表时间: 2021-09
• 期刊: Genome research
• 影响因子: 7
• 作者: Tock AJ;Holland DM;Jiang W;Osman K;Sanchez-Moran E;Higgins JD;Edwards KJ;Uauy C;Franklin FCH;Henderson IR
• 通讯作者: Henderson IR

Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.

• DOI: 10.1073/pnas.2021970118
• 发表时间: 2021-08-17
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Zhu L;Fernández-Jiménez N;Szymanska-Lejman M;Pelé A;Underwood CJ;Serra H;Lambing C;Dluzewska J;Bieluszewski T;Pradillo M;Henderson IR;Ziolkowski PA
• 通讯作者: Ziolkowski PA

The genetic and epigenetic landscape of the Arabidopsis centromeres.

拟南芥着丝粒的遗传和表观遗传景观。

• DOI: 10.17863/cam.78413
• 发表时间: 2021
• 作者: Naish M