MODULATION OF EXPERIMENTAL OXYGEN-INDUCED RETINOPATHY

实验性氧诱发视网膜病变的调节

• 批准号: 3262014
• 负责人: DALE L. PHELPS
• 金额: $ 16.55万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1989-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262014
• 关键词: disease /disorder model; hypoxia; infant animal; respiratory oxygenation; retina disorder; shock

Retinopathy of prematurity (ROP) is a disorder affecting an estimated 5000-6000 premature infants annually in the United States leaving approximately 2000 of them with some visual impairment, and 600 blind. There is little understanding as to why regression or healing of the retinopathy occurs in most of the affected infants while in the others it progresses to vision loss. The goal of this research is to test systemic oxygenation and perfusion factors that clinical surveys reveal as significantly correlated with severe ROP. These factors may control the regression process, and their study lead to clinically applicable therapy. The oxygen induced retinopathy kitten model will be used. Low flow oxygen therapy (28%) following an oxygen induced injury (80% oxygen) in 3 day old kittens will be tested first as a potential therapeutic maneuver suggested by a previous kitten study of variable oxygenation following injury. Second, Chronic hypoxia alone as an inducer of retinopathy will be tested since hypoxia following a high oxygen injury does result in a worse retinopathy. Because human infants with severe recurrent apneic spells and infants how have experienced perinatal asphyxia and/or shock are at increased risk for severe ROP, these physiologic conditions will be the 3rd and 4th hypotheses tested in the kitten to learn if they will reproducibly affect the oxygen induced retinopathy. Oxygen, administered in excess, has dominated the beliefs and attention of physicians as the etiology of ROP for too long, blinding investigators to other possible factors at work. One phase of the proposed research hopes to establish (or discredit) hypoperfusion as an initial insult causing retinopathy in the animal model. Of equal importance, the other phases of the reserach should firmly establish the role of hypoxia during the recovery process of this retinopathy leading to the organization of appropriate clinical trials.

早产儿视网膜病变（ROP）是一种影响早产儿视网膜病变的疾病。 据估计，美国每年有5000-6000名早产儿， 其中大约2000人留下了一些 600个盲人 人们几乎不了解 为什么视网膜病变的消退或愈合发生在大多数 受影响的婴儿，而在其他人，它的进展， 视力丧失 本研究的目的是测试系统的 临床调查显示， 与严重ROP显著相关。 这些因素可能 控制回归过程，他们的研究导致 临床上适用的治疗。 将使用氧诱导视网膜病变小猫模型。 低 氧气诱导损伤后的流量氧疗（28%） (80%氧气）将首先进行测试， 前一只小猫提出的潜在治疗策略 创伤后可变氧合研究。 第二、 慢性缺氧单独作为视网膜病变的诱导剂， 因为高氧损伤后的缺氧确实会导致 更严重的视网膜病变 因为患有严重 反复发作的呼吸暂停和婴儿如何经历 围产期窒息和/或休克的风险增加， 严重的ROP，这些生理条件将是第三， 第四个假设在小猫测试，以了解他们是否会 可重复地影响氧诱导的视网膜病变。 氧气，管理过量，已占主导地位的信念， 医生对ROP病因的关注时间过长， 使研究者对其他可能起作用的因素保持盲态。 一 该研究的目的是建立（或 低灌注作为初始损伤， 视网膜病变动物模型。 同样重要的是， 研究的其他阶段应牢固确立 在视网膜病变的恢复过程中 从而组织适当的临床试验。