MODULATION OF EXPERIMENTAL OXYGEN-INDUCED RETINOPATHY

早产儿视网膜病变(ROP)是一种影响 据估计，美国每年有5000-6000名早产儿 给大约2000个州留下了一些视觉上的 损伤，600人失明。人们对……的理解很少 为什么视网膜病变的退行性或愈合性多见于 受影响的婴儿，而在其他人中进展到 视力丧失。这项研究的目标是测试系统 临床调查显示的氧合和血流灌注因素 AS与重度ROP显著相关。这些因素可能 控制回归过程，他们的研究导致 临床适用的治疗方法。 将采用氧诱导视网膜病变小猫模型。低 氧源性损伤后的流动氧疗(28%) (80%氧气)3日龄小猫将首先作为一种 之前的一只小猫建议的潜在治疗手法 创伤后可变氧合作用的研究。第二, 仅慢性低氧作为视网膜病变的诱因将是 因为高氧损伤后的缺氧确实会导致测试 出现了更严重的视网膜病变。因为人类婴儿患有严重的 复发性呼吸暂停发作和婴儿如何经历 围产期窒息和/或休克的风险增加 严重的ROP，这些生理状况将是第3和 第四个假设在小猫身上进行了测试，以了解它们是否会 重复性地影响氧诱导的视网膜病变。 过量的氧气一直主导着人们的信念和 作为ROP病因的内科医生关注太久， 调查人员对其他可能起作用的因素视而不见。一 拟议研究阶段希望建立(或 名誉扫地])血液灌流不足是一种最初的侮辱 动物模型中的视网膜病变。同样重要的是， 研究的其他阶段应牢固确立这一角色 在这种视网膜病变的恢复过程中的低氧 从而组织适当的临床试验。

Retinopathy of prematurity (ROP) is a disorder affecting an estimated 5000-6000 premature infants annually in the United States leaving approximately 2000 of them with some visual impairment, and 600 blind. There is little understanding as to why regression or healing of the retinopathy occurs in most of the affected infants while in the others it progresses to vision loss. The goal of this research is to test systemic oxygenation and perfusion factors that clinical surveys reveal as significantly correlated with severe ROP. These factors may control the regression process, and their study lead to clinically applicable therapy. The oxygen induced retinopathy kitten model will be used. Low flow oxygen therapy (28%) following an oxygen induced injury (80% oxygen) in 3 day old kittens will be tested first as a potential therapeutic maneuver suggested by a previous kitten study of variable oxygenation following injury. Second, Chronic hypoxia alone as an inducer of retinopathy will be tested since hypoxia following a high oxygen injury does result in a worse retinopathy. Because human infants with severe recurrent apneic spells and infants how have experienced perinatal asphyxia and/or shock are at increased risk for severe ROP, these physiologic conditions will be the 3rd and 4th hypotheses tested in the kitten to learn if they will reproducibly affect the oxygen induced retinopathy. Oxygen, administered in excess, has dominated the beliefs and attention of physicians as the etiology of ROP for too long, blinding investigators to other possible factors at work. One phase of the proposed research hopes to establish (or discredit) hypoperfusion as an initial insult causing retinopathy in the animal model. Of equal importance, the other phases of the reserach should firmly establish the role of hypoxia during the recovery process of this retinopathy leading to the organization of appropriate clinical trials.