MULTICENTER BVOS: MACULAR EDEMA DATA ANALYSIS

多中心 BVOS：黄斑水肿数据分析

• 批准号: 3262153
• 负责人: DANIEL FINKELSTEIN
• 金额: $ 9.55万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1988-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262153
• 关键词: eye circulation; eye disorder diagnosis; eye fundus photography; human subject; lasers; longitudinal human study; macular drusen; mathematical model; model design /development; prognosis; retinography; statistics /biometry

For the 139 patients who were followed from 2 to 7 years in the Collaborative Branch Vein Occlusion Study, the proposed study will investigate 1) statistical analysis of retinal vascular photographic characteristics related to prognosis, laser treatment adequacy, and edema mechanisms, and 2) new statistical methods for the analysis of visual acuity. This group of 139 patients has now been closed out from the Collaborative Study with the major goal for this group achieved and published. Through this work, it has been established that laser photocoagulation is beneficial in lessening visual loss from macular edema that is secondary to retinal branch vein occlusion, for those patients who meet the eligibility requirements of the study and who were treated with the argon laser according to the study protocol. This proposal will review the photographic documentation of retinal characteristics that may be expected to offer a more accurate prognosis to the individual patient. Such features will include anatomical extent and severity of edema, presence of foveal hemorrhage, intact peri-foveal capillaries, etc. New statistical methodologies will be explored to examine 1) the time course of visual acuity change, 2) the stability of visual acuity, and 3) approaches to combining the expression of both vision gain and loss. The analyses of prognostic features (risk factors), through an examination of these abnormalities, may have relevance to other retinal vascular diseases, such as diabetic retinopathy.

对于139例随访2至7年的患者， 协作分支静脉闭塞研究，拟定研究将 研究1）视网膜血管摄影统计学分析 与预后、激光治疗充分性和水肿相关的特征 机制，和2）新的统计方法，用于分析视觉 敏锐度 这组139名患者现已从协作组中关闭 研究的主要目标为这个群体实现和出版。 通过 这项工作，它已被确定，激光光凝是 有益于减轻继发于黄斑水肿的视力丧失， 视网膜分支静脉阻塞，对于符合资格的患者 研究要求和接受氩激光治疗的患者 根据研究方案。 本提案将审查视网膜病变的摄影文件 这些特征可能会提供更准确的预后， 个别病人。 这些特征将包括解剖学范围和 水肿的严重程度，存在中心凹出血，中心凹周围完整 毛细管等。 将探索新的统计方法，以审查1）时间 视力变化过程，2）视力稳定性，3） 结合视觉增益和损失的表达的方法。 通过检查分析预后特征（风险因素） 这些异常，可能与其他视网膜血管 糖尿病视网膜病变等疾病。