MULTICENTER BVOS: MACULAR EDEMA DATA ANALYSIS

对139名患者进行了2年至7年的随访 协作性分支静脉阻塞研究，拟议的研究将 调查1)视网膜血管照相的统计分析 与预后、激光治疗充分性和水肿相关的特征 机制，以及2)视觉分析的新统计方法 敏锐度。 这个由139名患者组成的小组现在已被从Collaborative 完成并出版了这一组的主要目标的研究。穿过 这项工作已经确定，激光光凝是 有益于减少继发性黄斑水肿造成的视力损失 视网膜分支静脉阻塞，适用于符合条件的患者 这项研究的要求和谁接受了Ar激光治疗 根据研究方案。 本提案将回顾视网膜的摄影文献。 可能会提供更准确的预后的特征 个别病人。这些特征将包括解剖范围和 水肿严重，黄斑中心凹出血，中心凹周围完整 毛细血管等。 将探索新的统计方法来检验1)时间 视力变化的过程，2)视力的稳定性，3) 结合视力增益和视力损失表达的方法。 通过检查分析预后特征(危险因素) 在这些异常中，可能与其他视网膜血管有关 疾病，如糖尿病视网膜病变。

For the 139 patients who were followed from 2 to 7 years in the Collaborative Branch Vein Occlusion Study, the proposed study will investigate 1) statistical analysis of retinal vascular photographic characteristics related to prognosis, laser treatment adequacy, and edema mechanisms, and 2) new statistical methods for the analysis of visual acuity. This group of 139 patients has now been closed out from the Collaborative Study with the major goal for this group achieved and published. Through this work, it has been established that laser photocoagulation is beneficial in lessening visual loss from macular edema that is secondary to retinal branch vein occlusion, for those patients who meet the eligibility requirements of the study and who were treated with the argon laser according to the study protocol. This proposal will review the photographic documentation of retinal characteristics that may be expected to offer a more accurate prognosis to the individual patient. Such features will include anatomical extent and severity of edema, presence of foveal hemorrhage, intact peri-foveal capillaries, etc. New statistical methodologies will be explored to examine 1) the time course of visual acuity change, 2) the stability of visual acuity, and 3) approaches to combining the expression of both vision gain and loss. The analyses of prognostic features (risk factors), through an examination of these abnormalities, may have relevance to other retinal vascular diseases, such as diabetic retinopathy.