RETINAL THICKNESS ANALYSIS OF CYCLIC VISUAL ACUITY CHANGES IN MACULAR EDEMA

黄斑水肿周期性视力变化的视网膜厚度分析

• 批准号: 6275598
• 负责人: DANIEL FINKELSTEIN
• 金额: $ 2.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275598
• 关键词: bioperiodicity; clinical research; edema; human subject; retina disorder; vision tests; visual perception

Two patients have been recruited and admitted to the General Clinical Research Center. These patients were admitted to study their macular edema which is a common cause of visual loss associated with several ocular conditions including diabetic retinopathy and vascular occlusions. Patients with macular edema often state that vision is worse in the morning and improves throughout the course of the day. In a previous study using the General Clinical Research Center some years ago, we found the visual acuity of 3 patients with macular edema to improve over the course of a day. This was not associated with changes in refractive error and we concluded that the fluctuation in visual acuity may well have been the result of a cyclic change in the macular edema. Since the time of that original study about 1 0 years ago, instrumentation has become available that can noninvasively measure retinal thickness as an objective measure to quantitate retinal thickness and document change in macular edema. The procedure is risk free to the patient.

招募了两名患者，并将其纳入普通临床研究 研究中心 这些患者被允许研究他们的黄斑 水肿是视力丧失的常见原因， 包括糖尿病视网膜病变和血管性视网膜病变的眼部病症 闭塞。 患有黄斑水肿的患者通常会说视力 早上更糟，一整天都在改善。 在 之前的一项研究使用了几年的综合临床研究中心 前，我们发现3例黄斑水肿患者的视力， 在一天的过程中得到改善。 这与变化无关 在屈光不正，我们的结论是，波动的视觉 敏锐度很可能是黄斑区周期性变化的结果， 水肿 从10年前的原始研究开始， 已经可以使用能够非侵入性测量 视网膜厚度作为定量视网膜 厚度和黄斑水肿的文件变化。 手术有风险 免费给病人。