CORTICAL PROCESSING OF VISUAL MOTION

视觉运动的皮质处理

• 批准号: 3260780
• 负责人: William T Newsome
• 金额: $ 11.39万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260780
• 关键词: behavior test; brain mapping; eye movements; neural information processing; visual tracking

My long-term objective is to understand how neural processing in extrastriate visual cortex contributes to visual perception and visually guided behavior. The proposed research will focus on an extrastriate pathway in monkeys which is thought to be primarily involved in the analysis of visual motion. This pathway begins in striate cortex and continues through the Middle Temporal area (MT) and the Medial Superior Temporal area (MST) before reaching visuomotor regions of the parietal lobe that process information in more complex ways. Insight gained from these studies in rhesus monkeys may well be applicable to the human visual system since the visual and oculomotor capabilities of rhesus monkeys are known to be very similar to those of man. In addition, recent neurological findings suggest that a specific cortical pathway for visual motion exists in humans as well. Experiments will be carried out in awake, behaving monkeys trained to perform simple visuomotor and visual detection tasks. 1) Behavioral experiments will test the effects of chemical lesions of MT on a monkey's ability to detect visual motion and spatio-temporal contrast. This line of investigation should produce firm behavioral data concerning the functional role of MT in visual perceptions. 2) Physiological experiments will concentrate on a quantitative analysis of visual and visuomotor responses of single neurons in MST. Particular attention will be paid to neurons in MST which are known to fire in response to visual stimulation and in response to smooth pursuit eye movements. Interactions of these inputs will be examined, and the neural signals which drive the pursuit-related response will be studied. These experiments will complement previous studies of neuronal responses to visual motion in striate cortex, MT, and the parietal lobe, and will thus complete an initial physiological survey of this cortical motion pathway.

我的长期目标是了解大脑中的神经处理 纹外视皮质有助于视觉感知和视觉 引导行为。 拟议的研究将集中在一个外纹 在猴子中，这一途径被认为主要涉及 视觉运动分析 这条通路始于纹状体皮层， 继续通过中颞区（MT）和内侧上级 颞区（MST）到达顶叶视区之前 以更复杂的方式处理信息。 从中获得的见解 对恒河猴的研究可能也适用于人类的视觉系统 由于已知恒河猴的视觉和视力能力 与人类非常相似。此外，最近的神经学研究结果 这表明人类存在一种特定的视觉运动皮层通路 也 实验将在清醒的、行为良好的猴子中进行， 执行简单的视觉和视觉检测任务。 1)行为 实验将测试MT化学损伤对猴子的影响 检测视觉运动和时空对比的能力。 这行 调查应产生关于功能的可靠行为数据， MT在视觉感知中的作用。 2)生理实验将 专注于视觉和视觉反应的定量分析 单个神经元的数量。 将特别注意神经元， 已知MST对视觉刺激做出反应， 对平稳的追踪眼球运动的反应。 这些输入的相互作用 将被检查，和神经信号驱动的追求相关的 将研究应对措施。 这些实验将补充以前的 研究纹状体皮层、MT和 顶叶，从而完成初步的生理调查 大脑皮层运动路径