FACTORS CONTROLLING PROTEIN SYNTHESIS

这项研究的总体目标是通过以下方法阐明其机制： 蛋白质合成的起始发生在真核生物中。 之一 我们的目标是确定和描述所有需要的因素， 小麦胚中mRNA翻译的起始，决定了 这些因素在启动过程中，以及这些因素如何在功能上 与哺乳动物的起始因子有关。 第二个目标是确定 酵母蛋白质合成起始所需的因素 线粒体核糖体，并确定这些因素是如何在功能上相关 真核细胞质起始因子和大肠杆菌起始因子 因素

The overall objective of this proposed research is to elucidate the mechanism by which initiation of protein synthesis occurs in eukaryotic organisms. One of our objectives is to identify and characterize all of the factors required for the initiation of translation of mRNA in wheat germ, determine the function of these factors in the initiation process, and how these factors are functionally related to the mammalian initiation factors. A second objective is to identify the factors required for the initiation of protein synthesis on yeast mitochondrial ribosomes and determine how these factors are functionally related to eukaryotic cytoplasmic initiation factors and to Escherichia coli initiation factors.