Generation of an In Vivo Senescent Cell Atlas: Across the life-course and in pathology

体内衰老细胞图谱的生成：跨越生命历程和病理学

• 批准号: BB/T013540/1
• 负责人: Nicholas Ktistakis
• 金额: $ 78.51万
• 依托单位: Babraham Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT013540%2F1
• 关键词: Generation; Vivo; Senescent; Cell; Atlas

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Direct methylation sequencing.

直接甲基化测序。

• DOI: 10.1038/s41589-023-01356-9
• 发表时间: 2023
• 期刊: Nature chemical biology
• 影响因子: 14.8
• 作者: Abakir A

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming.

• DOI: 10.7554/elife.71624
• 发表时间: 2022-04-08
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Gill, Diljeet;Parry, Aled;Santos, Fatima;Okkenhaug, Hanneke;Todd, Christopher D.;Hernando-Herraez, Irene;Stubbs, Thomas M.;Milagre, Ines;Reik, Wolf
• 通讯作者: Reik, Wolf

Spatial profiling of early primate gastrulation in utero.

• DOI: 10.1038/s41586-022-04953-1
• 发表时间: 2022-09
• 期刊: Nature
• 影响因子: 64.8
• 作者: Bergmann S;Penfold CA;Slatery E;Siriwardena D;Drummer C;Clark S;Strawbridge SE;Kishimoto K;Vickers A;Tewary M;Kohler TN;Hollfelder F;Reik W;Sasaki E;Behr R;Boroviak TE
• 通讯作者: Boroviak TE

DNMT3A binds ubiquitinated histones to regulate bivalent genes.

• DOI: 10.1038/s41588-022-01073-4
• 发表时间: 2022-05
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Parry AJ;Reik W
• 通讯作者: Reik W

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming.

• DOI: 10.1111/acel.13578
• 发表时间: 2022-03
• 期刊: Aging cell
• 影响因子: 7.8
• 作者: Chondronasiou D;Gill D;Mosteiro L;Urdinguio RG;Berenguer-Llergo A;Aguilera M;Durand S;Aprahamian F;Nirmalathasan N;Abad M;Martin-Herranz DE;Stephan-Otto Attolini C;Prats N;Kroemer G;Fraga MF;Reik W;Serrano M
• 通讯作者: Serrano M