HUMAN POPULATION GENETICS

我们的主要兴趣是人类进化，利用新的 分子遗传学的发展。为此，我们研究了基因的多态现象。 核DNA，我们希望继续并得出合理的结论 我们对100个限制性片段长度多态(RFLP)的检测 全世界至少有15-20个土著人口。具有现代感 自动化技术方面，这部分项目的完成将是 再快点。 使用这些RFLP数据作为比较的基础，我们希望实现 过渡到更高效的PCRP(聚合酶链式反应多态)，并将 允许我们检查更多的人口。对于某些类别的PCRP，这些类别 从技术角度看特别有吸引力(CA重复)， 在口译方面有潜在的困难，我们倾向于采用 一种多重策略，通过分析两到三种不同类型的PCR ；记号笔。我们建议初步测试CA重复序列和ASO(等位基因- 特定的寡核苷酸检测到了PCRP，可能还有其他的。它也是 重要的是从在多种族样本上选择的多态性开始 避免目前为止研究的所有多态中存在的偏见，这些多态是 最初是在欧洲人身上选择的。 我们还计划继续研究基因和基因的并行性。 语言进化树，以及遗传和 文化现象。

Our major interest is human evolution, taking advantage of the new developments in molecular genetics. To this aim we study polymorphisms of nuclear DNA, and we want to continue and bring to a reasonable conclusion our tests of 100 restriction fragment length polymorphisms (RFLPs on at least 15-20 aboriginal populations of the entire world. With modern automation techniques, the completion of this part of the project will be faster. Using these RFLP data as a basis of comparison, we want to effect the transition to PCRPs (PCR polymorphisms) which are more efficient, and will allow us to examine more populations. For some categories of PCRPs, which are especially attractive from a technical point of view (CA repeats), there are potential difficulties in interpretation and we prefer to adopt a multiple strategy, by analyzing two or three different types of PCR ;markers. We propose to test initially both CA repeats and ASO (allele- specific oligonucleotides detected PCRPs, and possibly others. It is also important to start with polymorphisms selected on multiracial samples to avoid the bias present in all polymorphisms so far studied, that were initially selected on Europeans. We also plan to continue our studies of parallelism of genetic and linguistic evolutionary trees, and other correlations between genetic and cultural phenomena.