HEMOPROTEIN MODEL COMPOUNDS MAGNETIC INTERACTIONS

这个项目的长期目标是了解分子化学 多中心金属蛋白，特别是细胞色素氧化酶和相关 血红素蛋白，并发现有关的基本新的化学现象 这样的系统。 采用了一种综合模型复合方法，强调 双核卟啉的确定性表征， 近距离接触金属。 铁卟啉与螯合铜将服务于 作为细胞色素氧化酶模型;更多样化的金属选择将允许 探索新的结构和化学反应性方面， 双核系统所特有的 将特别强调 理解顺磁金属/金属中的自旋耦合现象， 金属/配体自由基体系。 单一犯罪的侦查手段 晶体X射线结构测定和变温磁 将沿着强调磁化率与各种光谱 技术（IR、UV-VIS Mossbauer、EPR等）。 对血红素蛋白及其相关的分子水平的详细了解 金属蛋白是基于基本的化学原理，必须 治疗金属蛋白紊乱的基本医学方法 （地中海贫血、镰状细胞贫血等）。

The long term goal of this project is to understand the molecular chemistry of multicenter metalloproteins, particularly cytochrome oxidase and related hemoproteins, and to uncover fundamental new chemical phenomena related to such systems. A synthetic model compound approach is taken which emphasizes the definitive characterization of binucleating porphyrins which hold two metals in close proximity. Iron porphyrins with chelated copper will serve as cytochrome oxidase models; a more diverse selection of metals will allow an exploration of new structural and chemical reactivity aspects that are unique to binuclear systems. Particular emphasis will be placed on understanding spin-coupling phenomena in paramagnetic metal/metal and metal/ligand radical systems. The investigative techniques of single crystal X-ray structure determination and variable temperature magnetic susceptibility will be emphasized along with a variety of spectroscopic techniques (IR, UV-VIS Mossbauer, EPR, etc.). A detailed molecular level understanding of hemoproteins and related metalloproteins is based on fundamental chemical principles and must underlie medical approaches to the therapy of metalloprotein disorders (thalassemias, sickle cell anemia, etc.).