HEMOPROTEIN MODEL COMPOUNDS MAGNETIC INTERACTIONS

这个项目的长期目标是了解分子化学。 多中心金属蛋白，特别是细胞色素氧化酶和相关的 血红蛋白，并揭示与以下相关的基本新化学现象 这样的系统。 采用了综合模型复合法，强调了综合模型复合法。 含两个基团的双核卟啉的确定化表征 近距离接触的金属。含络合铜的铁卟啉将提供服务 作为细胞色素氧化酶的模型；更多样化的金属选择将允许 对新的结构和化学反应方面的探索 是双核系统所特有的。我们将特别强调 了解顺磁性金属/金属中的自旋耦合现象 金属/配体自由基体系。一案的侦查技巧 晶体X射线结构测定与变温磁性 磁化率将与各种光谱一起强调 技术(IR、UV-Vis穆斯堡尔、EPR等)。 在分子水平上详细了解血球蛋白及其相关物质 金属蛋白以基本的化学原理为基础，必须 治疗金属蛋白紊乱的基础医学方法 (地中海贫血、镰状细胞性贫血等)。

The long term goal of this project is to understand the molecular chemistry of multicenter metalloproteins, particularly cytochrome oxidase and related hemoproteins, and to uncover fundamental new chemical phenomena related to such systems. A synthetic model compound approach is taken which emphasizes the definitive characterization of binucleating porphyrins which hold two metals in close proximity. Iron porphyrins with chelated copper will serve as cytochrome oxidase models; a more diverse selection of metals will allow an exploration of new structural and chemical reactivity aspects that are unique to binuclear systems. Particular emphasis will be placed on understanding spin-coupling phenomena in paramagnetic metal/metal and metal/ligand radical systems. The investigative techniques of single crystal X-ray structure determination and variable temperature magnetic susceptibility will be emphasized along with a variety of spectroscopic techniques (IR, UV-VIS Mossbauer, EPR, etc.). A detailed molecular level understanding of hemoproteins and related metalloproteins is based on fundamental chemical principles and must underlie medical approaches to the therapy of metalloprotein disorders (thalassemias, sickle cell anemia, etc.).