A DYNAMIC AND FLEXIBLE MANUFACTURING PLATFORM: INTENSIFYING BIOCATALYSIS FOR FRAGRANCE AND API PRODUCTION

动态且灵活的制造平台：强化香料和 API 生产的生物催化

• 批准号: BB/V000497/1
• 负责人: Thomas Wirth
• 金额: $ 32.21万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FV000497%2F1
• 关键词: DYNAMIC; FLEXIBLE; MANUFACTURING; PLATFORM; INTENSIFYING

Chemists can make novel compounds and materials, but the tools of synthetic methodology must be continuously expanded and improved for the sustainable production of compounds and materials as the needs from society for new or improved medicines and other compounds are high. Environmentally benign processes to satisfy that demand will increase the quality of life in many aspects. In our proposed research program, we will introduce a new method for mixing solutions during a reaction. The benefits of such high-performance mixing are numerous, shortened reaction times and therefore much higher productivities are envisioned which we could already demonstrate during preliminary experiments. In close collaboration with an SME company, Bioextractions Wales, we plan to synthesise fragrance molecules using this approach. After having established the principle and taken first steps to upscale some of the processes with the help of larger equipment available at BioExtractions Wales, we will extend the use of biocatalytic processes to the production of compounds (API's) necessary for the synthesis of drug molecules. Also, these technically more demanding reactions will be performed on a large scale at the companies' site. In addition, we will investigate the 'strength' of mixing and the relation to the outcome of the enzymatic reactions, before introducing further and automated optimisation through inline analysis of the reaction mixtures. This will all support the overall target of this proposal, which is the development of new and efficient processes for the environmentally friendly and resource-cautious industrial-scale synthesis of compounds used as fragrances and for the synthesis of drugs.

化学家可以制造新的化合物和材料，但由于社会对新的或改进的药物和其他化合物的需求很高，因此必须不断扩大和改进合成方法的工具，以便可持续地生产化合物和材料。满足这种需求的无害环境过程将在许多方面提高生活质量。在我们提出的研究计划中，我们将介绍一种在反应过程中混合溶液的新方法。这种高性能混合的好处很多，缩短了反应时间，因此可以设想更高的生产率，我们已经可以在初步实验中证明。在与中小企业bioextraction Wales公司的密切合作下，我们计划用这种方法合成香味分子。在建立了原理并采取了第一步，在威尔士生物萃取公司的大型设备的帮助下，将一些工艺升级，我们将把生物催化工艺的使用扩展到合成药物分子所需的化合物（API）的生产。此外，这些技术要求更高的反应将在公司现场大规模进行。此外，我们将研究混合的“强度”以及与酶促反应结果的关系，然后通过对反应混合物的在线分析引入进一步的自动化优化。这些都将支持本提案的总体目标，即开发新的高效工艺，用于环境友好和资源谨慎的工业规模合成用于香料和药物合成的化合物。