NEW DIRECTIONS IN FLOW ELECTROSYNTHESIS

流式电合成的新方向

• 批准号: EP/T019719/1
• 负责人: Thomas Wirth
• 金额: $ 59.73万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FT019719%2F1
• 关键词: NEW; DIRECTIONS; FLOW; ELECTROSYNTHESIS

Chemists have the exceptional ability to make novel compounds and materials yet, the tools of synthetic methodology must be continuously expanded and improved for the sustainable production of chemicals to meet increasing demands from industry. Industry, in turn, must satisfy the needs from society as novel or improved medicines, materials and environmentally benign processes will increase the quality of life in many aspects. Therefore, the development of novel reagents and processes with significantly superior environmental and industry-relevant credentials over existing methods will enhance the contribution of organic chemistry to science and its impact on society. We propose novel approaches to employ flow electrochemistry in biphasic organic synthesis. We will enhance mixing capabilities which will allow the generation and use of unstable short-lived intermediates in synthesis. Previously impossible reactions could now become feasible by exploiting the synthetic potential of flow microreactors in electrochemistry. Methods requiring stoichiometric amounts of reagents are replaced by sustainable sequences using exclusively electricity. Fast analysis of flow reactions through direct coupling will lead to fast (and computer-led) decisions for optimising complete processes.Our research program will contribute to improved sustainability by establishing a general protocol for flexible syntheses of new compounds. The EPSRC has acknowledged the importance of higher sustainability in chemistry by introducing a series of 'grand challenges' including Dial-a-Molecule (100% efficient synthesis) to which our program is making a contribution.

化学家拥有制造新化合物和新材料的非凡能力，然而，为了化学品的可持续生产，必须不断扩大和改进合成方法的工具，以满足工业日益增长的需求。反过来，工业必须满足社会的需要，因为新的或改进的药物、材料和无害环境的工艺将在许多方面提高生活质量。因此，与现有方法相比，开发具有明显优于环境和行业相关证书的新试剂和工艺将增强有机化学对科学的贡献及其对社会的影响。我们提出了在双相有机合成中应用流动电化学的新方法。我们将提高混合能力，这将允许在合成中产生和使用不稳定的短寿命中间体。通过利用流动微反应器在电化学中的合成潜力，以前不可能的反应现在变得可行。需要化学计量量试剂的方法被只使用电的可持续序列所取代。通过直接耦合对流动反应进行快速分析，将为优化整个过程带来快速（由计算机主导）的决策。我们的研究计划将通过建立灵活合成新化合物的通用协议，为提高可持续性做出贡献。EPSRC通过引入一系列“重大挑战”，包括Dial-a-Molecule（100%高效合成），认识到更高可持续性在化学领域的重要性，我们的项目正在为此做出贡献。

项目成果

Biphasic organic synthesis with continuous electro-flow

• DOI: 10.1016/j.cogsc.2024.100896
• 发表时间: 2024-02-27
• 期刊: CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
• 影响因子: 9.3
• 作者: Mizar，Pushpak;Arepally，Sagar;Wirth，Thomas
• 通讯作者: Wirth，Thomas

Memory of chirality in a room temperature flow electrochemical reactor.

• DOI: 10.1038/s41598-020-73957-6
• 发表时间: 2020-10-06
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Hardwick T;Cicala R;Wirth T;Ahmed N
• 通讯作者: Ahmed N