C-N BOND FORMATION USING METAL-BASED REAGENTS

该提案概述了利用过渡金属有机金属试剂的计划 开发形成碳-碳（C-C）的新合成方法， 有机分子中的碳-氮（C-N）键。 在C-C领域，研究 集中在反应，涉及插入乙炔到 金属-碳键，因此是针对合成取代的 烯烃。 将特别注意的是分子内版本的 该反应可用于构建五元环， 例如在类胡萝卜素和类固醇的D环中发现的那些。 在C-N 在这一领域，该提案的重点是将NO插入金属-碳键。 这 提供了一种利用NO将氮原子结合到有机分子中的方法 气体作为氮源。 将研究两种类型的反应。 在 第一，分子R-X中的另一个反应性官能团X被取代， 氮原子 第二种类型涉及1，2-二胺化（和1，2加成， 氮官能团和CO片段）转化为烯烃。 该反应产生 在广泛的生理活性中发现的功能性， 含氮有机分子，如生物碱，氨基酸， 镇痛剂和抗高血压剂。

This proposal outlines plans to utilize transition metal organometallic reagents to develop new synthetic methods for forming carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds in organic molecules. In the C-C area, the research concentrates on reactions which involve insertion of acetylenes into metal-carbon bonds, and thus is directed toward the synthesis of substituted alkenes. Particular attention will be paid to the intramolecular version of this reaction, which can be applied to the construction of five-membered rings, such as those found in prostaglandins and the D-ring of steroids. In the C-N area, the proposal focuses on insertion of NO into metal-carbon bonds. This provides a way of incorporating nitrogen atoms into organic molecules using NO gas as a source of nitrogen. Two types of reaction will be investigated. In the first, another reactive functionality X in a molecule R-X is replaced by a nitrogen atom. The second type involves 1,2-diamination (and 1,2 addition of a nitrogen function and CO fragment) to an alkene. This reaction generates functionality found in a wide range of physiologically active, nitrogen-containing organic molecules, such as alkaloids, amino acids, analgesics, and antihypertensive agents.