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BIOCHEMISTRY OF GENE EXPRESSION IN HIGHER EUKARYOTES

BIOCHEMISTRY OF GENE EXPRESSION IN HIGHER EUKARYOTES
高等真核生物基因表达的生物化学
批准号：
3271965
负责人：
Bruce M Alberts
金额：
$10.78万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-08-01 至 1987-07-31
来源：
https://reporter.nih.gov/project-details/3271965
关键词：
acetylation chromatin estradiol eukaryote gene expression genetic manipulation genetic regulation

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中文摘要
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英文摘要
Two of the three major objectives of the research program supported by this grant remain unchanged from the original proposal. The first of these involves the use of a combination of biochemical and genetic approaches to decipher the biological role of histone acetylation in higher eukaryotes. The second objective is to uncover some of the molecular details of the process whereby positional information is imparted to cells during embryogenesis, using as a model system the specification of anterio-posterior position by the "zone of polarizing activity" (ZPA) in the early chick limb bud. A newer objective concerns determining the biological role of mammalian type II DNA topoisomerases, new enzymes recently discovered in this laboratory which we suspect are intimately involved in the initiation of eukaryotic DNA replication.
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MOLECULAR CYTOLOGY STUDY SECTION
  • 批准号：
    3554878
  • 项目类别：
  • 资助金额：
    $2.89万
  • 财政年份：
    1984
  • 负责人：
    Bruce M Alberts
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS
MOLECULAR CYTOLOGY STUDY SECTION
  • 批准号：
    3554877
  • 项目类别：
  • 资助金额：
    $6.5万
  • 财政年份：
    1984
  • 负责人：
    Bruce M Alberts
  • 依托单位：
    U.S. PHS PUBLIC ADVISORY GROUPS
BIOCHEMISTRY OF GENE EXPRESSION IN HIGHER EUKARYOTES
BIOCHEMISTRY OF GENE EXPRESSION IN HIGHER EUKARYOTES
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