The contribution of capsular and subcapsular progenitor cells in homeostatic adrenal cortex self-renewal and zonal-specific remodelling.
被膜和被膜下祖细胞在稳态肾上腺皮质自我更新和区域特异性重塑中的贡献。
基本信息
- 批准号:BB/V007246/1
- 负责人:
- 金额:$ 59.91万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2021
- 资助国家:英国
- 起止时间:2021 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The onset of menopause in women, the decrease in testosterone secretion in men after the age of 40 and the decrease in production of growth hormone from the brain are well-recognised biological changes affecting our endocrine system as we age. The adrenal glands are two small organs located on top of the kidneys. The outer part of each gland, called the adrenal cortex, is essential for life, as it is the main site of production of steroid hormones. These steroid hormones affect carbohydrate metabolism and control the stress response, control blood volume and salt balance, and influence blood pressure.The adrenal cortex "reproduces itself" over time (a process called self-renewal), and a group of cells (called stem cells) which we have identified in the outermost layers of the gland are responsible for generating new steroid-producing cells throughout our lifetime. The aging adrenal is a poorly investigated area, despite the importance of the gland in human health and disease. Even less, the contribution of stem cells to the generation of new hormone-producing cells during our lifetime is entirely unknown. With this proposal we aim at determining differences in the ability of adrenal stem cells to make new steroid-producing cells between young and adults, males and females, with a particular emphasis on cells which produce the hormones aldosterone and corticosterone.
随着年龄的增长,女性更年期的开始,男性40岁后睾酮分泌的减少以及大脑生长激素的减少都是影响我们内分泌系统的公认生物学变化。肾上腺是两个小器官位于肾脏的顶部。每个腺体的外部部分,称为肾上腺皮质,对生命至关重要,因为它是产生类固醇激素的主要场所。这些类固醇激素影响碳水化合物代谢,控制应激反应,控制血容量和盐平衡,并影响血压。肾上腺皮质随着时间的推移“自我复制”(一个称为自我更新的过程),我们已经确定的一组细胞(称为干细胞)在腺体的最外层负责在我们的一生中产生新的类固醇产生细胞。尽管肾上腺在人类健康和疾病中的重要性,但衰老的肾上腺是一个研究较少的领域。更少的是,干细胞在我们一生中对产生新的细胞的贡献是完全未知的。有了这个建议,我们的目标是确定肾上腺干细胞的能力,使新的类固醇生产细胞之间的年轻人和成年人,男性和女性的差异,特别强调细胞产生的激素醛固酮和皮质酮。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants.
- DOI:10.3389/fendo.2023.1105602
- 发表时间:2023
- 期刊:
- 影响因子:5.2
- 作者:
- 通讯作者:
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Leonardo Guasti其他文献
Rare variants in the emMECP2/em gene in girls with central precocious puberty: a translational cohort study
中枢性性早熟女孩 emMECP2/em 基因罕见变异:一项转化队列研究
- DOI:
10.1016/s2213-8587(23)00131-6 - 发表时间:
2023-08-01 - 期刊:
- 影响因子:41.800
- 作者:
Ana P M Canton;Flávia R Tinano;Leonardo Guasti;Luciana R Montenegro;Fiona Ryan;Deborah Shears;Maria Edna de Melo;Larissa G Gomes;Mariana P Piana;Raja Brauner;Rafael Espino-Aguilar;Arancha Escribano-Muñoz;Alyssa Paganoni;Jordan E Read;Márta Korbonits;Carlos E Seraphim;Silvia S Costa;Ana Cristina Krepischi;Alexander A L Jorge;Alessia David;Ana Claudia Latronico - 通讯作者:
Ana Claudia Latronico
Microbiological characterization of a population affected by periodontitis with different levels of bone health
不同骨骼健康水平的受牙周炎影响人群的微生物学特征
- DOI:
10.57582/ijbf.230302.078 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Leonardo Guasti;L. Cianferotti;B. Pampaloni;M. Duradoni;Francesco Tonelli;Magda Passafaro;Francesco Martelli;T. Iantomasi;M. L. Brandi - 通讯作者:
M. L. Brandi
Leonardo Guasti的其他文献
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{{ truncateString('Leonardo Guasti', 18)}}的其他基金
Generation of functional adrenocortical organoids from mice and humans and their preclinical testing as cell-based therapy for adrenal insufficiency
从小鼠和人类中生成功能性肾上腺皮质类器官及其作为肾上腺功能不全细胞疗法的临床前测试
- 批准号:
MR/X021017/1 - 财政年份:2024
- 资助金额:
$ 59.91万 - 项目类别:
Research Grant
LINEAGE CONVERSION OF BLOOD-DERIVED ENDOTHELIAL PROGENITOR CELLS TO AN ADRENOCORTICAL PHENOYPE: A NEW TECHNOLOGY TO STUDY THE ADRENAL GLAND.
血源性内皮祖细胞向肾上腺皮质表型的谱系转换:研究肾上腺的新技术。
- 批准号:
BB/L002671/1 - 财政年份:2014
- 资助金额:
$ 59.91万 - 项目类别:
Research Grant
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