19-BBSRC-NSF/BIO Phage host range evolution in spatially structured microbiomes

19-BBSRC-NSF/BIO 空间结构微生物组中的噬菌体宿主范围进化

• 批准号: BB/V011464/1
• 负责人: Wolfram Moebius
• 金额: $ 56.87万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FV011464%2F1
• 关键词: 19; BBSRC; NSF; BIO; Phage

Bacteriophages, the viral parasites of bacteria, are major agents of bacterial death in microbial communities or microbiomes. Previous work has shown that phage host range, the type of bacteria a given phage can successfully infect, can evolve rapidly. This evolution alters the impact that phage have on the composition and function of microbial communities. However, this previous work has focused on bacteria growing in well-mixed conditions while many bacteria in microbiomes exist in aggregations known as biofilms. Not only is the spatial arrangement of bacteria different in biofilms, but also their physiology or lifestyle. The proposed research will pair state of the art computer simulations with cutting edge experimental approaches to develop and test theory for predicting the impact that bacteriophage have on bacterial communities. This work will improve our ability to manage microbial communities that are vital for human health and industrial applications.

噬菌体是细菌的病毒寄生虫，是微生物群落或微生物组中细菌死亡的主要病原体。以前的工作表明，噬菌体宿主的范围，即特定噬菌体可以成功感染的细菌类型，可以迅速进化。这种进化改变了噬菌体对微生物群落组成和功能的影响。然而，先前的工作主要集中在细菌在混合良好的条件下生长，而微生物组中的许多细菌以称为生物膜的聚集形式存在。不仅细菌在生物膜中的空间排列不同，而且它们的生理或生活方式也不同。拟议的研究将结合最先进的计算机模拟和尖端的实验方法来开发和测试预测噬菌体对细菌群落影响的理论。这项工作将提高我们管理微生物群落的能力，这些微生物群落对人类健康和工业应用至关重要。

项目成果

Bacteriophage specificity is impacted by interactions between bacteria

• DOI: 10.1128/msystems.01177-23
• 发表时间: 2024-02-20
• 期刊: MSYSTEMS
• 影响因子: 6.4
• 作者: Bisesi，Ave T.;Moebius，Wolfram;Harcombe，William R.
• 通讯作者: Harcombe，William R.

Assisted percolation of slow-spreading mutants in heterogeneous environments.

协助异质环境中缓慢传播的突变体的渗透。

• DOI: 10.1103/physreve.108.044401
• 发表时间: 2023
• 期刊: Physical review. E
• 作者: Tunstall T