Nanobody Discovery Hub

纳米抗体发现中心

• 批准号: BB/V018523/1
• 负责人: Ray Owens
• 金额: $ 119.35万
• 依托单位: Rosalind Franklin Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FV018523%2F1
• 关键词: Nanobody; Discovery; Hub

The genomics revolution has opened up the protein world for discovery research in medicine, biosciences and biotechnology. Interpreting and exploiting this information necessitates an understanding of how proteins function as part of complex and dynamic macro-molecular assemblies in cells. Single domain antibodies or nanobodies are powerful tools for tagging and tracking proteins and their interactions. They can lock proteins into specific shapes that makes it easier to study their structure. By making nanobody technology more widely available to the UK Biosciences research community, the Nanobody Discovery Hub project will help accelerate research into how proteins work and how this knowledge can be usefully applied in structural, cell and synthetic biology.

基因组学革命为医学、生物科学和生物技术的发现研究打开了蛋白质世界。解释和利用这些信息需要了解蛋白质如何作为细胞中复杂和动态的大分子组装的一部分发挥作用。单域抗体或纳米抗体是标记和跟踪蛋白质及其相互作用的强大工具。它们可以将蛋白质锁定成特定的形状，从而更容易研究它们的结构。通过使纳米体技术更广泛地为英国生物科学研究界所用，纳米体发现中心项目将有助于加快对蛋白质如何工作以及如何将这种知识有效地应用于结构、细胞和合成生物学的研究。

项目成果

Chemistry towards Biology-Instruct: Snapshot.

• DOI: 10.3390/ijms232314815
• 发表时间: 2022-11-26
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Hricovini, Milos;Owens, Raymond J.;Bak, Andrzej;Kozik, Violetta;Musial, Witold;Pierattelli, Roberta;Majekova, Magdalena;Rodriguez, Yoel;Musiol, Robert;Slodek, Aneta;Starha, Pavel;Pietak, Karina;Slota, Dagmara;Florkiewicz, Wioletta;Sobczak-Kupiec, Agnieszka;Jampilek, Josef
• 通讯作者: Jampilek, Josef