Optical Fluorescence Micro and Nanoscopy to determine and quantify functional molecular interactions and dynamics across time and length scales

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Light microscopy forms a bedrock of modern research in bioscience and medicine, allowing processes to be examined across scales from individual molecules up to living organisms. Here we propose to acquire a high-end recently released system to enable us to perform state-of-the-art "super resolution" microscopy, with the possibility to perform time-resolved imaging at molecular level. This will allow us to study events in cells with unparalleled spatial and temporal resolution. Critically, these systems will permit BBSRC-funded and other researchers to drive research projects understanding the fundamental mechanisms driven by molecules, its interactions and dynamics at the single cellular level up to collective functional assemblies of cells. The microscope will be part of Imperial's "Facility for Imaging and Light microscopy" (FILM) and accessible to all members of College, as well as local, national and international collaborators.