21-ICRAD: Tackling chronic wasting disease in Europe

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Chronic wasting disease (CWD) is a prion disease that affects deer, similar to BSE or "mad cow disease" of cattle. Unlike BSE, there is as yet no evidence that it can spread to humans, but it has become very widespread in wild and farmed deer across North America, with major impacts on population numbers in some areas. In 2016, CWD was found for the first time in Europe, in a wild reindeer in Norway, and since then more cases have been found in reindeer, moose and red deer in Norway and neighbouring countries. The characteristics of the prions from these cases are distinctly different from those found in North America, suggesting that they have not arisen from importation of CWD. There are also major differences between Europe and North America in the species of wild deer, their population sizes and distribution, habitat and management. These differences mean that lessons learned from the experience of CWD in North America do not necessarily apply when planning control of the disease in Europe. This research project will address gaps in our knowledge, with the aim of developing targeted and cost-effective ways to detect CWD and limit its spread within European deer populations. We will use information about CWD cases in Norway and Sweden and deer populations in these countries to develop mathematical tools that help decisions about where to direct disease detection efforts, and predict the spread of the disease, so that control strategies can be devised and tested. These tools can be adapted and applied in other European countries if CWD is found there in future. We will also assess whether there is genetic resistance to CWD among any of the major breeds of wild and farmed deer in Europe, since selective breeding for disease resistance may help in control or prevention of spread. Finally, we will examine the likelihood that European CWD strains could spread to farmed livestock (e.g. sheep, cattle and pigs) or people, by experimental infection of mice that have been genetically altered to mimic the prion susceptibility of each species, as well as alternative laboratory methods. The research consortium working on this project brings together expertise and resources from leading European research groups working on animal and human prion diseases. The outcomes of the project will provide evidence on the potential impacts of CWD in Europe, which will be vital in understanding the risks and planning effective ways to control and prevent adverse effects of the disease on animal, human and environmental health.