STRUCTURE AND FUNCTION OF LUCIFERASE

荧光素酶的结构和功能

• 批准号: 3287236
• 负责人: BRIAN W MATTHEWS
• 金额: $ 5.78万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3287236
• 关键词: Vibrio; X ray crystallography; electron density; enzyme structure; luciferin monooxygenase; photochemistry

Our objective is to determine the three-dimensional structure of bacterial luciferase by the method of X-ray crystallography. Recent success in obtaining large crystals of the protein makes this a feasible undertaking. This will be the first known structure of any bioluminescent system and will be a major step toward understanding the phenomenon of light emission. The study will also contribute to our understanding of the structure and function of biological systems in general and flavin-proteins in particular.

我们的目标是确定细菌的三维结构 用X射线结晶学方法测定了荧光素酶活性。最近在以下方面取得了成功 获得蛋白质的大晶体使这项工作成为一项可行的任务。 这将是第一个已知的任何生物发光系统的结构 将是理解光发射现象的重要一步。 这项研究也将有助于我们对结构和 生物系统的功能，特别是黄素蛋白。