Multifunctional particles for biological applications

用于生物应用的多功能颗粒

• 批准号: DP170103331
• 负责人: Prof Frank Caruso
• 金额: $ 29.61万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170103331
• 关键词: Multifunctional; particles; biological; applications

This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.

该项目旨在设计多功能颗粒，检查它们的生物相互作用，并创造用于细胞靶向、细胞内化、亚细胞药物释放和改善药代动力学的颗粒。工程颗粒对纳米医学中的药物输送非常重要。尽管已经开发了各种基于颗粒的递送系统，但很少有实现商业化的，这主要是因为与生物屏障相关的问题和挑战。该项目将开发一个具有定制特性的颗粒组装平台，有望为基于颗粒的治疗提供关于颗粒-生物相互作用的见解。