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Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions

Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions
生物涂层对纳米颗粒与免疫细胞相互作用的影响
批准号:
DP210103114
负责人:
Prof Frank Caruso
金额:
$47.53万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2021
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2021-05-03 至 2024-05-02

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项目成果

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中文摘要
翻译
纳米材料暴露在血液或淋巴液等生物环境中,迅速在其表面吸附一层生物分子,形成生物分子电晕,并深刻改变其性质。该项目旨在通过结合粒子工程、免疫学、蛋白质组学和生物信息学分析来解决生物分子冠状病毒对纳米粒子-免疫细胞相互作用的影响。该项目的预期成果是在纳米材料免疫细胞行为方面产生新的知识,并为纳米粒子设计原则,在农业、兽医和生物医学部门具有潜在的应用前景。
英文摘要
Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outcomes are to generate new knowledge in nanomaterial–immune cell behaviour and design principles for nanoparticles with prospective applications in the agricultural, veterinary and biomedical sectors.
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Engineering Functional Antimicrobial Polypeptide Surfaces
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海外基金