Engineering Functional Antimicrobial Polypeptide Surfaces

工程功能性抗菌多肽表面

• 批准号: DP240102343
• 负责人: Prof Frank Caruso
• 金额: $ 42.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102343
• 关键词: Engineering; Functional; Antimicrobial; Polypeptide; Surfaces

Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.

抗菌涂层对防止细菌污染至关重要，但不存在通用的解决方案。结构纳米工程抗菌肽聚合物（SNAPPs）最近被开发用于对抗多重耐药细菌。为了将其应用于各种表面的抗菌涂层，需要一种简单而通用的涂层策略。通过开发酚醛功能化snap，该项目旨在利用金属酚醛材料的粘附特性，快速涂覆各种表面，包括不锈钢和纺织品。预期的结果是产生抗菌多肽表面，这将有利于食品安全，医疗植入技术和先进纺织品。