SYNTHETIC ACTIVE SITES FOR CATALYSIS OF BOND FORMATION
用于催化成键的合成活性位点
基本信息
- 批准号:3295907
- 负责人:
- 金额:$ 14.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-02-01 至 1995-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The ability to construct, at will, "artificial" enzymes for which no
natural counterparts exist, would have a profound effect on chemical
synthesis. For such artificial enzymes could be employed to selectively
catalyze many reactions that are presently either chemically or
economically infeasible. In the long-term, these synthetic catalysts may
also contribute to the pharmacopeia of human medicine, being used not only
in production of new pharmaceuticals, but also (perhaps in micro-
encapsulated form) for directly treating a variety of illnesses - illnesses
resulting from a sufferer's inability to (i) properly process biological
precursors or (ii) metabolize/excrete by-products or toxins.
The objective of this project is to construct two fully synthetic active
sites (1/1') designed to catalyze bond formation. Each active site, which
is an organic molecule with a molecular weight < 1,000, contains substrate
binding sites and a catalytic unit and is intended to exhibit catalysis,
selectivity, and turnover. The two active sites will employe transition
state stabilization to achieve their catalytic activity. The synthesis of
1/1', which takes advantage of the commercial availability of large
subunits, should afford 1/1' by a highly convergent route in which the
longest synthetic sequence is little more than a dozen steps in length.
Synthetases 1/1' are intended to operate in organic solvents, because they
use hydrogen bonding for recognition and binding. Alternatives to 1/1' are
also described to allow for the possibility that unexpected difficulties
with 1/1' may surface.
The proposal outlines the strategies reflected in the design of 1/1' and
details how individual elements in the concept of 1/1' (including substrate
binding, transition state stabilization, proton transfer, flexibility vs.
rigidity, product release, turnover and selectivity) will be incorporated,
measured and optimized. For the ultimate goal is to demonstrate that the
design concepts are general in nature, and can be easily applied to the
solution of a virtually unlimited array of synthetic and other practical
problems.
随意构建“人工”酶的能力,而这些酶是没有能力构建的
天然对应物的存在将对化学产生深远的影响
合成。 对于这种人工酶,可以用来选择性地
催化许多目前化学或化学反应
经济上不可行。 从长远来看,这些合成催化剂可能
也为人类医学的药典做出了贡献,不仅被使用
在新药品的生产中,而且(也许在微观领域)
胶囊形式)可直接治疗多种疾病 - 疾病
由于患者无法(i)正确处理生物
前体或(ii)代谢/排泄副产物或毒素。
该项目的目标是构建两个完全合成的活性物质
设计用于催化键形成的位点(1/1')。 每个活动站点,
是分子量 < 1,000 的有机分子,包含底物
结合位点和催化单元,旨在表现出催化作用,
选择性和周转率。 两个活动地点将进行员工过渡
状态稳定以实现其催化活性。 的合成
1/1',它利用了大型的商业可用性
子单元,应通过高度收敛的路线提供 1/1',其中
最长的合成序列长度只有十几步。
合成酶 1/1' 旨在在有机溶剂中操作,因为它们
利用氢键进行识别和结合。 1/1' 的替代方案是
还描述了考虑到意外困难的可能性
1/1' 可能会浮出水面。
该提案概述了 1/1' 和
详细说明了 1/1' 概念中的各个元素(包括基材
结合、过渡态稳定、质子转移、灵活性与稳定性
刚性、产品释放、周转和选择性)将被纳入,
测量和优化。 因为最终目标是证明
设计理念本质上是通用的,可以很容易地应用于
几乎无限的合成和其他实用解决方案
问题。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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T. ROSS KELLY其他文献
T. ROSS KELLY的其他文献
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