THE EPIDEMIOLOGY OF EARLY REPRODUCTIVE LOSS

坚持流行病学、细胞遗传学和病理学相结合的方法 在早期生殖丧失的持续研究中。进一步的一系列 病例(有自然流产的妇女)和对照(有 怀孕持续超过28周)将从一家医院招聘。 一份新的问卷将深入调查咖啡因的影响 含饮料(咖啡、茶、可乐和其他软饮料)； 目前正在分析的与选定的其他风险暴露有关的数据将 被收集起来。研究中的结果包括自然流产 染色体正常受孕；非整倍体受精卵；流产 指形态异常的胎儿；出生体重、妊娠和 对照分娩的生存能力。一项前瞻性研究，很早就进行 将开发将妊娠丢失作为感兴趣的终点。母性 选定病例的血清将通过生物测定进行胚胎毒性测试 血液样本将被储存起来，以供将来分析。

A combined epidemiologic, cytogenetic and pathologic approach is sustained in the continuing study of early reproductive loss. A further series of cases (women having spontaneous abortions) and controls (women whose pregnancies continue beyond 28 weeks) will be recruited from one hospital. A new questionnaire will investigate intensively the effects of caffeine containing beverages (coffee, tea, colas and other soft drinks); further data relating to selected other exposures, at present under analysis, will be collected. Outcomes under study include spontaneous abortion of a chromosomally normal conceptus; conception of an aneuploid zygote; abortion of a morphologically abnormal conceptus; birthweight, gestation and viability among control births. A prospective study, with very early pregnancy loss as an endpoint of interest, will be developed. Maternal serum of selected cases will be tested for embryotoxicity using a bioassay system; blood specimens will be stored for future analysis.