Epidemiology of Ovarian Age

描述(由申请者提供)：本研究的目标是确定 影响卵巢年龄的因素。我们将“卵巢年龄”定义为 卵母细胞池。卵泡(卵母细胞)计数在出生前最高， 随着女性年龄的增长，卵泡的数量会减少；同样，在 随着女性年龄的增长，每个月经周期都会减少。在任何特定的年龄段， 女性的卵母细胞池大小和窦数各不相同。 (发育中的)卵泡。这些差异可能反映了 卵池形成时或卵母细胞闭锁的比率。数量不断增加 女性将生育推迟到晚年。因为卵巢老化是 伴随着受孕延迟和不孕不育风险的增加 三体受孕--卵巢加速症危险因素的识别 老龄化将对生殖研究和初级保健产生重大影响 预防。 拟议的研究利用已经完成的两项研究的数据来确定 卵巢年龄的危险因素。在第一项研究中，卵巢年龄是通过 494名妇女的绝经过渡开始年龄和绝经年龄。在 第二项研究。卵巢年龄是在指数怀孕后不久通过 卵巢有腔卵泡计数与卵巢三项激素指标 173例女性的年龄--卵泡刺激素、抑制素B和雌二醇。两者都有 研究包括关于产妇特征和暴露的广泛数据， 可能会影响卵巢衰老。因此，它们提供了一种出色和独特的 有机会(I)确定育龄妇女卵巢年龄的决定因素 自然周期和(Ii)检查卵巢年龄的决定因素在 生育年限与绝经过渡期的决定因素不同。 具体目标是： 1.检查产妇的特征(例如，体重指数)或 暴露(如吸烟)与卵巢年龄有关，通过(I)衡量 有腔卵泡计数，(Ii)选定的激素指标，(Iii)发病年龄 绝经过渡期的年龄，以及(Iv)绝经年龄。 2.使用卵母细胞研究的数据进行探索性研究，以评估 X基因失活是否偏斜与卵巢年龄的增加有关。

DESCRIPTION (provided by applicant): The goal of this study is to identify factors that influence ovarian age. We define "ovarian age" as the size of oocyte pool. Ovarian follicle (oocyte) counts are highest before birth and decrease as women age; similarly, the number of follicles that develop during each menstrual cycle decreases as women age. At any particular chronologic age, women vary in both the size of their oocyte pools and the number of antral (developing) follicles. These variations may reflect differences in the size of the pool at its formation or in rates of oocyte atresia. Increasing numbers of women are deferring childbearing to the later years. Since ovarian aging is accompanied by conception delay and an increased risk of infertility and trisomic conception, the identification of risk factors for accelerated ovarian aging would have significant implications for reproductive research and primary prevention. The proposed study draws on data from two already completed studies to identify risk factors for ovarian age. In the first study, ovarian age is measured by age at onset of the menopausal transition and at menopause in 494 women. In the second study. ovarian age is measured shortly after an index pregnancy by counts of ovarian antral follicles and three hormonal indicators of ovarian age-follicle stimulating hormone, inhibin B and estradiol-in 173 women. Both studies include extensive data on maternal characteristics and exposures that might influence ovarian aging. They thus provide an excellent and unique opportunity to (i) identify determinants of ovarian age in fertile women during natural cycles and (ii) examine whether determinants of ovarian age during the reproductive years differ from determinants during the menopausal transition. The specific aims are: 1. To examine whether maternal characteristics (e.g., body mass index) or exposures (e.g., smoking) are associated with ovarian age measured by (i) antral follicle counts, (ii) selected hormonal indicators, (iii) age at onset of the menopausal transition, and (iv) age at menopause. 2. To conduct exploratory studies, using data from the Oocyte study, to assess whether or not skewed X-inactivation is associated with advanced ovarian age.