Epidemiology of Ovarian Age

描述（由申请人提供）：本研究的目的是确定 影响卵巢年龄的因素我们将"卵巢年龄"定义为 卵母细胞池卵巢卵泡（卵母细胞）计数在出生前最高， 随着女性年龄的增长而减少;同样，在女性发育过程中， 随着女性年龄的增长，每个月经周期都会减少。在任何特定的年龄， 女性在卵母细胞池的大小和窦的数量上都有差异， （发育中的）卵泡。这些变化可能反映了不同的大小， 在其形成或卵母细胞闭锁率池。越来越多的 妇女将生育推迟到晚年。由于卵巢老化是 伴随着受孕延迟和不孕风险增加， 三体妊娠，促排卵危险因素的鉴定 老龄化将对生殖研究和初级 预防 拟议的研究利用了两项已经完成的研究的数据， 卵巢年龄的危险因素在第一项研究中，卵巢年龄是通过 494名妇女绝经过渡期开始时和绝经时的年龄。在 第二项研究。卵巢年龄在指数妊娠后不久测量， 卵巢窦卵泡计数和卵巢三项激素指标 年龄-促卵泡激素，雌二醇B和雌二醇-173名妇女。两 研究包括关于母体特征和暴露的广泛数据， 可能会影响卵巢衰老。他们是一个优秀的和独特的。 有机会（i）确定育龄妇女卵巢年龄的决定因素， 自然周期和（ii）检查卵巢年龄的决定因素是否在 生育年限与绝经过渡期的决定因素不同。 具体目标是： 1.检查是否有母体特征（例如，体重指数）或 暴露（例如，吸烟）与卵巢年龄相关，通过（i） 窦卵泡计数，（ii）选定的激素指标，（iii）发病年龄 绝经过渡期，和（iv）绝经年龄。 2.使用卵母细胞研究的数据进行探索性研究，以评估 X染色体失活是否与卵巢年龄提前有关。

DESCRIPTION (provided by applicant): The goal of this study is to identify factors that influence ovarian age. We define "ovarian age" as the size of oocyte pool. Ovarian follicle (oocyte) counts are highest before birth and decrease as women age; similarly, the number of follicles that develop during each menstrual cycle decreases as women age. At any particular chronologic age, women vary in both the size of their oocyte pools and the number of antral (developing) follicles. These variations may reflect differences in the size of the pool at its formation or in rates of oocyte atresia. Increasing numbers of women are deferring childbearing to the later years. Since ovarian aging is accompanied by conception delay and an increased risk of infertility and trisomic conception, the identification of risk factors for accelerated ovarian aging would have significant implications for reproductive research and primary prevention. The proposed study draws on data from two already completed studies to identify risk factors for ovarian age. In the first study, ovarian age is measured by age at onset of the menopausal transition and at menopause in 494 women. In the second study. ovarian age is measured shortly after an index pregnancy by counts of ovarian antral follicles and three hormonal indicators of ovarian age-follicle stimulating hormone, inhibin B and estradiol-in 173 women. Both studies include extensive data on maternal characteristics and exposures that might influence ovarian aging. They thus provide an excellent and unique opportunity to (i) identify determinants of ovarian age in fertile women during natural cycles and (ii) examine whether determinants of ovarian age during the reproductive years differ from determinants during the menopausal transition. The specific aims are: 1. To examine whether maternal characteristics (e.g., body mass index) or exposures (e.g., smoking) are associated with ovarian age measured by (i) antral follicle counts, (ii) selected hormonal indicators, (iii) age at onset of the menopausal transition, and (iv) age at menopause. 2. To conduct exploratory studies, using data from the Oocyte study, to assess whether or not skewed X-inactivation is associated with advanced ovarian age.