RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM

红细胞酪氨酸激酶和代谢调节

基本信息

  • 批准号:
    3298950
  • 负责人:
  • 金额:
    $ 13.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-12-01 至 1993-11-30
  • 项目状态:
    已结题

项目摘要

With the observation that tyrosine-protein kinases are commonly involved in cell growth control, significant effort has been devoted to understanding the identities, distributions and biochemical actions of these kinases. Such research has recently yielded the curious observation that elevated levels of tyrosine kinase activity are not only associated with rapidly growing and transformed cells, but in some cases also with quiescent, terminally differentiated cells. Since information on the roles of tyrosine kinases in nondividing cells might also provide insight into one or more aspects of their activities in transformed cells, we have undertaken an investigation of the regulation of the tyrosine kinase of erythrocytes and its influence on the properties of the major substrate band 3, especially on its ability to bind and regulate glycolytic enzymes. We intend to purify the above kinase and determine which endogenous/exogenous ligands modulate its activity. We also plan to determine whether activation/inhibition of the kinase in vivo regulates erythrocyte metabolism, as suggested from recent in vitro kinase in vivo regulates erythrocyte metabolism, as suggested from recent in vitro studies. Finally, because glycolytic rates and tyrosine kinase activity are often elevated in transformed cells, we plan to investigate the tyrosine phosphorylation of glycolytic enzyme binding proteins in nonerythroid cells in an attempt to understand the role they may play in the regulation of cell metabolism.
观察到酪氨酸蛋白激酶通常参与其中

项目成果

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PHILIP Stewart LOW其他文献

PHILIP Stewart LOW的其他文献

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{{ truncateString('PHILIP Stewart LOW', 18)}}的其他基金

Project 2: Near-Infrared Targeted Tracers for Intraoperative Identification of NSCLC
项目2:用于术中识别NSCLC的近红外靶向示踪剂
  • 批准号:
    10647645
  • 财政年份:
    2022
  • 资助金额:
    $ 13.34万
  • 项目类别:
Project 2: Near-Infrared Targeted Tracers for Intraoperative Identification of NSCLC
项目2:用于术中识别NSCLC的近红外靶向示踪剂
  • 批准号:
    10333065
  • 财政年份:
    2022
  • 资助金额:
    $ 13.34万
  • 项目类别:
Near infrared intraoperative molecular imaging of lung adenocarcinoma
肺腺癌近红外术中分子影像
  • 批准号:
    9198209
  • 财政年份:
    2016
  • 资助金额:
    $ 13.34万
  • 项目类别:
Near infrared intraoperative molecular imaging of lung adenocarcinoma
肺腺癌近红外术中分子影像
  • 批准号:
    9030040
  • 财政年份:
    2016
  • 资助金额:
    $ 13.34万
  • 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
  • 批准号:
    6712779
  • 财政年份:
    2002
  • 资助金额:
    $ 13.34万
  • 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
  • 批准号:
    6622784
  • 财政年份:
    2002
  • 资助金额:
    $ 13.34万
  • 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
  • 批准号:
    6455374
  • 财政年份:
    2002
  • 资助金额:
    $ 13.34万
  • 项目类别:
1999 GORDON CONFERENCE ON THE RED CELL
1999 年戈登红细胞会议
  • 批准号:
    2807356
  • 财政年份:
    1999
  • 资助金额:
    $ 13.34万
  • 项目类别:
RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM
红细胞酪氨酸激酶和代谢调节
  • 批准号:
    2180639
  • 财政年份:
    1988
  • 资助金额:
    $ 13.34万
  • 项目类别:
RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM
红细胞酪氨酸激酶和代谢调节
  • 批准号:
    3298949
  • 财政年份:
    1988
  • 资助金额:
    $ 13.34万
  • 项目类别:

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