Near infrared intraoperative molecular imaging of lung adenocarcinoma
肺腺癌近红外术中分子影像
基本信息
- 批准号:9030040
- 负责人:
- 金额:$ 69.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-03-01 至 2021-02-28
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressApplications GrantsBiocompatibleBiologyBiomedical ResearchBody cavitiesCancer DetectionCancer PatientCanis familiarisCaringCellsCharacteristicsChemistryCholecystokinin B ReceptorClinicalClinical DataClinical TrialsCollaborationsCompanionsContrast MediaCurative SurgeryDataDetectionDevelopmentDiagnostic Neoplasm StagingDiseaseDrainage procedureDyesEGF geneEnsureEpidermal Growth Factor ReceptorExcisionFacultyFeasibility StudiesFolic AcidFollow-Up StudiesGenetic HeterogeneityGoalsGrantHigh PrevalenceHumanImageImage-Guided SurgeryImageryIndustryJointsLaboratoriesLeftLungLung AdenocarcinomaLung NeoplasmsLymphaticMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of lungMapsMicrometastasisModelingMolecularMusNear-infrared optical imagingNeoplasm MetastasisNoduleOperating RoomsOperative Surgical ProceduresOpticsPaperPatient CarePatient-Focused OutcomesPatientsPeer Review GrantsPennsylvaniaPhasePhenotypePolypsPreparationPrimary NeoplasmProductionPublishingPulmonary PathologyRecurrenceRelapseResearch Project GrantsResectableResectedResidual TumorsResidual stateSolid NeoplasmSpecificityStagingSurgeonSurvival RateTechnologyTestingThoracic Surgical ProceduresTimeTissuesToxicologyTracerTranslatingTranslationsUnited StatesUniversitiesVeterinary MedicineWorkbasebioimagingbody cavitycancer cellcancer imagingcancer surgerycapsuleclinical applicationclinically relevantcollaborative environmentdrug developmentexperienceimage guidedimaging agentimprovedinnovationinnovative technologiesintraoperative imaginglymph nodesmolecular imagingneoplastic cellnew technologyoperationparticlepre-clinicalpreventpublic health relevancestandard of caretumortumor heterogeneity
项目摘要
DESCRIPTION (provided by applicant): The primary goal of this Biomedical Research Grant is to translate imaging agents for intraoperative cancer detection and image-guided surgery. Half of all cancer patients undergo surgery to remove their tumor. The single most important predictor of patient survival is a complete surgical resection of the primary tumor, draining lymph
nodes, and metastatic lesions. However, up to 40% of surgical patients leave the operating room with malignant cells remaining after resection. Thus, there are urgent unmet needs to develop new and innovative technologies that can assist the surgeon in ensuring complete tumor resection by delineating tumor margins, and identifying micrometastases and draining lymph nodes. We propose a new technology to image patients at the conclusion of the standard-of-care cancer operation in order to discover residual local disease before completing the surgery. While the proposed technologies are broadly applicable to solid tumors, this project is specifically committed to improving detection of lung adenocarcinomas, one of the most aggressive human malignancies. To accomplish this goal, we have assembled a collaborative team at University of Pennsylvania and Purdue University with synergistic expertise in clinical trials, folate biology, chemistry, lung pathology, thoracic surgery and veterinary medicine. The proposed work will optimize three distinct types of contrast agents for a translational intraoperative imaging clinical trial. The first contrast agent uses folate to target a conjugated NIR dye specifically to malignant tissue. The folate-NIR agent will be evaluated in a first-in- human clinical trial of lung adenocarcinoma patients in order to determine if there is a benefit of
intraoperative imaging to standard-of-care surgical approaches. The second contrast agent uses the same targeting approach to deliver a near-infrared dye for EGFR and CCK2R to cancer cells and allow better imaging of diseased cells more deeply buried in the tissues. This will allow for precise tumor localization and more accurate resection of cancers without violating the tumor capsule or seeding the body cavity.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHILIP Stewart LOW其他文献
PHILIP Stewart LOW的其他文献
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{{ truncateString('PHILIP Stewart LOW', 18)}}的其他基金
Project 2: Near-Infrared Targeted Tracers for Intraoperative Identification of NSCLC
项目2:用于术中识别NSCLC的近红外靶向示踪剂
- 批准号:
10647645 - 财政年份:2022
- 资助金额:
$ 69.83万 - 项目类别:
Project 2: Near-Infrared Targeted Tracers for Intraoperative Identification of NSCLC
项目2:用于术中识别NSCLC的近红外靶向示踪剂
- 批准号:
10333065 - 财政年份:2022
- 资助金额:
$ 69.83万 - 项目类别:
Near infrared intraoperative molecular imaging of lung adenocarcinoma
肺腺癌近红外术中分子影像
- 批准号:
9198209 - 财政年份:2016
- 资助金额:
$ 69.83万 - 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
- 批准号:
6712779 - 财政年份:2002
- 资助金额:
$ 69.83万 - 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
- 批准号:
6622784 - 财政年份:2002
- 资助金额:
$ 69.83万 - 项目类别:
Tumor-Specific Targeting of Folate-Derivatized Drugs
叶酸衍生药物的肿瘤特异性靶向
- 批准号:
6455374 - 财政年份:2002
- 资助金额:
$ 69.83万 - 项目类别:
RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM
红细胞酪氨酸激酶和代谢调节
- 批准号:
2180639 - 财政年份:1988
- 资助金额:
$ 69.83万 - 项目类别:
RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM
红细胞酪氨酸激酶和代谢调节
- 批准号:
3298949 - 财政年份:1988
- 资助金额:
$ 69.83万 - 项目类别:
RED CELL TYROSINE KINASES AND REGULATION OF METABOLISM
红细胞酪氨酸激酶和代谢调节
- 批准号:
3298950 - 财政年份:1988
- 资助金额:
$ 69.83万 - 项目类别:
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