ENZYME IN ORGANIC SYNTHESIS--CONSTRUCTION OF POLYHYDROXY

有机合成酶--多羟基的构建

• 批准号: 3303329
• 负责人: CHI-HUEY WONG
• 金额: $ 19.69万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3303329
• 关键词: O glycosidase; X ray crystallography; aldehyde lyase; carbohydrate analog; carbohydrate biosynthesis; chemical binding; chemical condensation; chemical structure function; chemical synthesis; cis trans isomerization; covalent bond; enzyme biosynthesis; enzyme inhibitors; gel electrophoresis; nuclear magnetic resonance spectroscopy; nucleic acid chemical synthesis; pentose phosphate; phosphomutase; piperidine; polyhydroxy compound; pyrrolidines; spermine

Many carbohydrates and derivatives are clinically important compounds or synthetically useful intermediates. The proposed investigation will develop practical procedures for the syntheses of carbohydrates and derivatives based on enzyme-catalyzed C-C bond and C-N bond formations. Six different aldolases will be used as catalysts for the syntheses of sugar related molecules of potential use as inhibitors of target enzymes. Nucleoside phosphorylase coupled with phosphopentomutase will be used for the synthesis of nucleosides useful as antiviral agents.

许多碳水化合物和衍生物是临床上重要的化合物或 合成有用的中间体。 拟议的调查将 开发合成碳水化合物的实用程序 基于酶催化的 C-C 键和 C-N 键形成的衍生物。 六种不同的醛缩酶将用作合成的催化剂 潜在用作靶标抑制剂的糖相关分子 酶。 核苷磷酸化酶与磷酸五肽变位酶偶联 用于合成可用作抗病毒剂的核苷。