课题基金 / 基金详情

LYSOSOMAL ENZYMES

LYSOSOMAL ENZYMES
溶酶体酶
批准号：
3316130
负责人：
JOHN S O'BRIEN
金额：
$14.44万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-12-01 至 1991-06-30
来源：
https://reporter.nih.gov/project-details/3316130
关键词：
arylsulfatases biological polymorphism chromosome translocation complementary DNA enzyme mechanism fucosidosis genetic mapping human population genetics inborn lysosomal enzyme disorder inborn metabolism disorder diagnosis laboratory mouse leukodystrophy linkage mapping lysozyme mannosidase metachromatic leukodystrophy molecular cloning molecular pathology nucleic acid probes nucleic acid sequence plasminogen protein sequence ribosomal RNA

项目摘要

项目成果

JOHN S O'BRIEN的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
This project is designed to determine the nucleic acid defects in human and canine alpha-L-fucosidosis, determine whether the electrophoretic enzyme polymorphism of human alpha-L- fucosidosis is coded by the structural FUC Al locus, and determine whether the low enzyme activity polymorphism of human alpha-L-fucosidase is coded by FUC Al. A second goal is to complete the isolation of a cDNA coding for arylsulfatase A, perform DNA sequence analysis for this cDNA, map the precise chromosomal location of ARSA and determine nucleic acid defects in human metachromatic leucodystrophy.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
3 LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
海外基金