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3 LYSOSOMAL ENZYMES

3 LYSOSOMAL ENZYMES
3 种溶酶体酶
批准号：
3316123
负责人：
JOHN S O'BRIEN
金额：
$12.61万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-12-01 至 1987-11-30
来源：
https://reporter.nih.gov/project-details/3316123
关键词：
chromosome complement complementary DNA fucosidosis genetic library genetic mapping human tissue inborn lysosomal enzyme disorder leukodystrophy lysozyme mannosidase metachromatic leukodystrophy molecular cloning molecular genetics molecular pathology ribosomal RNA

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中文摘要
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英文摘要
Three human lysosomal genes, Alpha-fucosidase, Alpha-mannosidase and arylsulfatase A will be cloned. cDNA's for each will be isolated from a human liver lambda gtll library by screening for antibody reactive plaques. Full-length cDNA's will be isolated and sequenced to establish colinearity with amino acid sequences for each protein. Comparisons with mutants with Alpha-fucosidosis, Alpha-mannosidosis, and metachromatic leukodystrophy will be made after analysis of mRNA and genomic fragments to establish the nucleic acid defects in selected cell lines.
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LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
3 LYSOSOMAL ENZYMES
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