IMMUNOREGULATION IN PREGNANCY

怀孕期间的免疫调节

• 批准号: 3314684
• 负责人: Gary W. Wood
• 金额: $ 14.71万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3314684
• 关键词: autoradiography; cellular immunity; flow cytometry; gene expression; granulocyte; histocompatibility antigens; immunofluorescence technique; immunoregulation; immunosuppression; laboratory mouse; lymphocyte; macrophage; mixed lymphocyte reaction test; placenta; placental transfer; pregnancy; pregnancy immunology; prostaglandins; spontaneous abortion; tissue /cell culture; uterus; vitelline membrane

This is a proposal to continue studies into the role of local immune regulation in preventing a maternal anti-fetal immune rejection. The underlying rationale is that the system may at times fail, leading to spontaneous abortion. Understanding the mechanisms may be important to decreasing the incidence of such failures. The operating theory is that protection of the developing embryo results from a combination of the immunologically inert physical barrier provided by the trophoblast and a region of local immunosuppression generated in the uterus around the fetus. This environment is generated during the decidual response through a massive increase in numbers of prostaglandin producing cells, principally macrophages. To explore this hypothesis, it is proposed that a study be performed of: 1) Control mechanisms influencing macrophage accumulation in the uterus during pregnancy, 2) Mechanism(s) responsible for immunoregulation by decidual macrophages, 3) The extent and nature of immunoregulation in uterine regional lymph nodes, 4) A model of indomethacin induced abortion which is closely relevant to the proposed immunoregulatory mechanisms. The above specific aims will be studied using a variety of cellular immune techniques in a mouse model system. In conclusion, these studies should lead to an extension of current knowledge of the immunology of pregnancy.

这是一个建议，继续研究局部免疫的作用， 调节预防母体抗胎儿免疫排斥反应。 的 基本原理是，系统有时可能会失败，导致 自然流产 了解这些机制可能对 从而降低了这种故障的发生率。 操作原理是， 保护发育中的胚胎是由以下因素的组合产生的： 滋养层提供的免疫惰性物理屏障和 在子宫周围产生的局部免疫抑制区域 胎儿 这种环境是在蜕膜反应过程中产生的， 前列腺素产生细胞数量的大量增加， 巨噬细胞 为了探讨这一假设，建议进行一项研究， 1）影响巨噬细胞积聚的控制机制， 2）负责的机制（S） 蜕膜巨噬细胞的免疫调节，3） 子宫区域淋巴结的免疫调节，4） 吲哚美辛引起的流产，这是密切相关的建议 免疫调节机制。 上述具体目标将通过以下方式进行研究： 在小鼠模型系统中的多种细胞免疫技术。 在 结论，这些研究应该导致现有知识的扩展 怀孕免疫学的研究。