Smart Controlled Release of Small Molecules

小分子的智能控制释放

• 批准号: EP/F068395/1
• 负责人: Zhibing Zhang
• 金额: $ 49.24万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF068395%2F1
• 关键词: Smart; Controlled; Release; Small; Molecules

There is a growing need to devise methods for stabilisation of active ingredients in liquid and control of their release to the right place at right time, covering a wide range of industrial applications, particularly in the area of small sized molecules. Examples include controlled release of perfumes from fabrics or cosmetic products, delivery of artificial diets to marine fish larvae, bacteriacides in food pipelines, insecticides on soft furnishings or foliage, dyes or inks, adhesives, and drugs in the body. The best way to achieve these objectives is using microcapsules. However, controlling the stability and release of the core chemicals have been proven to be not well understood. In particular, controlling leakage of small molecules is extremely challenging and has not been achieved so far, which has limited the impact and suitability of microcapsules for wide applications. It is proposed to prepare microcapsules having dual shells, which combines the concepts of triggered release (the outer shell may be broken by applied mechanical force) and sustained release (the inner shell with certain permeability). The aim of this project is to formulate and characterise novel double-shell microcapsules with desirable structure and mechanical properties in order to realise stabilisation and controlled delivery of active ingredients made of small molecules, via collaboration between chemical engineering (Professor Z Zhang's group) and chemistry (Professor J Preece and Professor B Vincent, Polymer and Colloid Group in the University Bristol), and between the academic groups and two international companies Appleton Paper Inc., USA, which has three manufacture sites in the UK as a manufacturer of industrial microcapsules and Procter and Gamble, UK (Professor D. York's Technology Breakthrough Group) as an end user of microcapsules.

越来越需要设计用于稳定液体中的活性成分并控制它们在正确的时间释放到正确的位置的方法，覆盖广泛的工业应用，特别是在小尺寸分子领域。例子包括从织物或化妆品中控制释放香水，向海洋鱼类幼虫提供人工饲料，食品管道中的杀菌剂，软家具或树叶上的杀虫剂，染料或墨水，粘合剂和体内药物。实现这些目标的最佳方法是使用微胶囊。然而，控制核心化学品的稳定性和释放已被证明是没有得到很好的理解。特别是，控制小分子的泄漏是极具挑战性的，迄今为止尚未实现，这限制了微胶囊广泛应用的影响和适用性。提出了制备具有双壳的微胶囊，其结合了触发释放（外壳可通过施加的机械力而破裂）和持续释放（具有一定渗透性的内壳）的概念。该项目的目的是通过化学工程和生物医学工程的合作，制定和开发具有理想结构和机械性能的新型双壳微胶囊，以实现小分子活性成分的稳定和可控递送。（张志忠教授小组）和化学（布里斯托大学聚合物和胶体小组的J Preece教授和B Vincent教授），以及学术小组与两家国际公司Appleton Paper Inc.之间，美国，该公司在英国拥有三个生产基地作为工业微胶囊的制造商，以及英国宝洁公司（D。约克的技术突破组）作为微胶囊的最终用户。

项目成果

Composite microcapsules with enhanced mechanical stability and reduced active ingredient leakage

• DOI: 10.1016/j.partic.2015.09.003
• 发表时间: 2016-06-01
• 期刊: PARTICUOLOGY
• 影响因子: 3.5
• 作者: Long, Yue;Song, Kai;Preece, Jon A.
• 通讯作者: Preece, Jon A.

Failure of elastic-plastic core-shell microcapsules under compression

• DOI: 10.1002/aic.12804
• 发表时间: 2012-09-01
• 期刊: AICHE JOURNAL
• 影响因子: 3.7
• 作者: Mercade-Prieto, Ruben;Allen, Rachael;Goodwin, Ted E.
• 通讯作者: Goodwin, Ted E.

Microcapsules with low content of formaldehyde: preparation and characterization

• DOI: 10.1039/b902832c
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF MATERIALS CHEMISTRY
• 作者: Long, Yue;York, David;Preece, Jon A.
• 通讯作者: Preece, Jon A.