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Exploring the Mechanisms of Human Gallbladder Pain

探索人类胆囊疼痛的机制

基本信息

批准号：
EP/G015651/1
负责人：
XiaoYu Luo
金额：
$ 41.03万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG015651%2F1
关键词：
Exploring Mechanisms Human Gallbladder Pain

项目摘要

Gallstone and other diseases of the biliary tract affect more than 10% of the adult population of the UK. Up to 60,000 operations to remove the gallbladder are performed in the UK each year, at a cost of approximately 40 million to the NHS. However, due to our lack of understanding of the pain mechanism, surgery is often conducted without any guarantee of relieving the symptoms. The purpose of this project is to explore the pain mechanism using a mechanical model. When gallbladder contracts during emptying, not only the intra-luminal pressure rises, but the size and shape of the gallbladder also change depending on the downstream flow condition. Consequently, the various stress distributions in the gallbladder muscle wall also change. We believe that it is the total stresses in the gallbladder, not the pressure or volume change, that play the key role in the gallbladder pain. We aim to establish this new concept by carrying out a non-linear stress analysis of the gallbladder models, including both the passive and the active stresses. This model will be tested against controlled clinical experiments for various subjects. The work proposed here is significant for understanding the gallbladder pain mechanism since this is the first approach using mechanical modelling of the human biliary system. Although it is generally believed that the pain receptors are likely to be mechano-sensitive, the precise link between these remains unclear. If the new concept can be confirmed in this project, it will provide a much clearer picture of the problem, and help with more efficient surgical diagnosis.

胆结石和其他胆道疾病影响了英国10%以上的成年人。在英国，每年进行多达6万例胆囊切除手术，NHS的费用约为4000万英镑。然而，由于我们对疼痛机制的了解不足，手术往往不能保证缓解症状。这个项目的目的是利用力学模型来探索疼痛的机制。当胆囊在排空过程中收缩时，不仅腔内压力升高，而且胆囊的大小和形状也会随着下游流动情况的变化而变化。因此，胆囊肌壁的各种应力分布也发生了变化。我们认为是胆囊的总压力，而不是压力或体积的变化，在胆囊疼痛中起着关键作用。我们的目标是通过对胆囊模型进行非线性应力分析，包括被动应力和主动应力，来建立这一新概念。该模型将在不同科目的对照临床实验中进行测试。这里提出的工作对于理解胆囊疼痛机制具有重要意义，因为这是第一个使用人体胆道系统机械建模的方法。尽管人们普遍认为疼痛感受器可能是机械敏感的，但它们之间的确切联系尚不清楚。如果这个新概念可以在这个项目中得到证实，它将提供一个更清晰的问题图景，并有助于更有效的手术诊断。