MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
批准号:
3315386
负责人:
JACK FISHMAN
金额:
$12.96万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-02-01 至 1987-01-31
中文摘要
雄激素向雌激素的转化包括三次羟基化,
英文摘要
The transformation of androgens to estrogens involves three hydroxylations,
the first two of which take place at the C-19 position and third at 2Beta.
The product of these reactions the 2Beta-hydroxy-19-aldehyde, is
transformed nonenzymatically to estrogen. An antibody to the 2Beta-hydroxy
aldehyde has been prepared and it inhibits estrogen formation by delaying
the collapse of the labile enzymatic product of placental aromatase. The
purpose of this project is to utilize this immunological probe and the high
specific activity androgen substrates which have been synthesized, to
examine the individual hydroxylations participating in estrogen
biosynthesis in tissues other than the placenta such as the gonads, brain
and adipose tissue. The step(s) in the aromatization sequence which are
influenced by pituitary hormones will be analyzed by means of the above
probes. The new radiolabeled substrates will be employed to examine
changes in peripheral aromatization in in vivo studies contrasting normals
and subjects with body weight distortions, as well as patients with liver
disease. The mechanism of estrogen biosynthesis will provide the basis for
the synthesis of structures which bid well to be effective and specific
aromatization inhibitors and can prove to be useful therapeutic agents in
diseases in which cessation of estrogen biosynthesis is desirable.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317429
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项目类别:
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资助金额:$17.86万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
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批准号:3315384
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项目类别:
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资助金额:$15.2万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317430
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项目类别:
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资助金额:$19.74万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317426
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项目类别:
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资助金额:$20.61万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
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批准号:3315387
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项目类别:
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资助金额:$12.5万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317431
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项目类别:
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资助金额:$19.21万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317428
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项目类别:
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资助金额:$18.34万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
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批准号:3315388
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项目类别:
-
资助金额:$15.06万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
COVALENT INTERACTIONS OF ESTROGENS IN TARGET TISSUES
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批准号:3317424
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项目类别:
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资助金额:$16.69万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
MECHANISM AND CONTROL OF ESTROGEN BIOSYNTHESIS
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批准号:3315389
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项目类别:
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资助金额:$14.42万
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财政年份:1984
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负责人:JACK FISHMAN
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依托单位:
PHYSIOLOGICAL FUNCTION OF 2-HYDROXYESTROGENS
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批准号:3313667
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项目类别:
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资助金额:$13.06万
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财政年份:1982
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负责人:JACK FISHMAN
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依托单位:
PHYSIOLOGICAL FUNCTION OF 2-HYDROXYESTROGENS
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批准号:3313668
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项目类别:
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资助金额:$12.69万
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财政年份:1982
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负责人:JACK FISHMAN
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依托单位:
ENDOCRINOLOGY AND CANCER
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批准号:3904531
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ENDOCRINOLOGY AND CANCER
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批准号:3948324
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ENDOCRINOLOGY AND CANCER
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批准号:3925778
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ENDOCRINE BIOMARKERS OF BREAST CANCER RISK
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批准号:4691619
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
NUTRITION AND STEROID HORMONE METABOLISM
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批准号:3904552
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ESTROGEN BIOSYNTHESIS
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批准号:3973476
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ENDOCRINOLOGY AND CANCER
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批准号:3973475
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
ESTROGEN BIOSYNTHESIS
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批准号:4701009
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:JACK FISHMAN
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依托单位:
海外基金