HINDLIMB MUSCLE ORGANOGENESIS AND NEURAL INTEGRATION
后肢肌肉器官发生和神经整合
基本信息
- 批准号:3319069
- 负责人:
- 金额:$ 7.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-07-01 至 1989-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Developmentally-caused limb defects constitute a major debilitating
disorder. In an attempt to evaluate the extent of variability from the
normal pattern of limb development, it is necessary that the various
systems contributing to normal limb development be systematically and
thoroughly evaluated.
It is proposed to study, in depth, the development, maturation and neural
integration of hindlimb musculature, with emphasis on the following
objectives:
1. Determination of the pattern of organogenesis of the fetal mouse soleus
muscle (a predominantly slow twitch muscle). This pattern of development
will be compared and contrasted with the pattern of development of the
extensor digitorum longus muscle (a fast twitch muscle).
2. Investigation of the complex interrelationship between the developing
muscle organ and the nervous system during the fetal and early neonatal
stages, including:
a. Establishment of the time course and pattern of myoneural integration.
b. Investigation of mechanisms which may be involved in the establishment
of polyneuronal innervation.
c. Correlation of developmental events occurring in fetal muscle with
maturational changes in the spinal cord (i.e. programmed motoneuron cell
death).
3. Investigation of the time course of myosin transition in developing
myofibers of future fast and slow hindlimb muscles, with emphasis of
isozyme transitions in single motor units during the period of polyneuronal
elimination.
In vivo studies of developing muscles of the hindlimb of the 129 ReJ mouse
will be carried out using spaced serial, section electron microscopic
techniques, computer assisted morphometric analyses, retrograde transport
of horseradish peroxidase, physiological and immunocytochemical techniques.
发育引起的肢体缺陷构成了一个主要的衰弱
disorder. 为了评估来自
正常的肢体发育模式,这是必要的,
促进正常肢体发育的系统是系统性的,
彻底评估。
建议深入研究,发展,成熟和神经
后肢肌肉组织的整合,重点如下
目的:
1.胎鼠比目鱼肌器官发生方式的测定
肌肉(主要是缓慢收缩的肌肉)。 这种发展模式
将比较和对比的发展模式,
伸趾长肌(一种快速收缩的肌肉)。
2.调查发展中国家与发展中国家之间的复杂相互关系
肌肉器官和神经系统在胎儿和新生儿早期
阶段,包括:
a.建立肌神经整合的时间进程和模式。
B.调查可能参与建立
多神经元的神经支配。
C.胎儿肌肉发生发育事件与
脊髓中的成熟变化(即程序化运动神经元细胞
死亡)。
3.发育中肌球蛋白转变时程的研究
肌纤维的未来快,慢后肢肌肉,重点是
多神经元期单个运动单位同工酶的变化
淘汰
129 ReJ小鼠后肢肌肉发育的体内研究
将使用间隔连续切片电子显微镜进行
技术,计算机辅助形态学分析,逆行转运
辣根过氧化物酶,生理和免疫细胞化学技术。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Morphometric analysis of the developing mouse soleus muscle.
发育中的小鼠比目鱼肌的形态测量分析。
- DOI:10.1002/aja.1001810306
- 发表时间:1988
- 期刊:
- 影响因子:0
- 作者:Ontell,M;Hughes,D;Bourke,D
- 通讯作者:Bourke,D
Muscular dystrophy and muscle regeneration.
肌营养不良和肌肉再生。
- DOI:10.1016/s0046-8177(86)80178-2
- 发表时间:1986
- 期刊:
- 影响因子:3.3
- 作者:Ontell,M
- 通讯作者:Ontell,M
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Marcia R. Ontell其他文献
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{{ truncateString('Marcia R. Ontell', 18)}}的其他基金
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
生肌因素:肌肉成熟和再生
- 批准号:
6652674 - 财政年份:2000
- 资助金额:
$ 7.25万 - 项目类别:
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
生肌因素:肌肉成熟和再生
- 批准号:
6190628 - 财政年份:2000
- 资助金额:
$ 7.25万 - 项目类别:
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
生肌因素:肌肉成熟和再生
- 批准号:
6375287 - 财政年份:2000
- 资助金额:
$ 7.25万 - 项目类别:
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
生肌因素:肌肉成熟和再生
- 批准号:
6797228 - 财政年份:2000
- 资助金额:
$ 7.25万 - 项目类别:
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
生肌因素:肌肉成熟和再生
- 批准号:
6534490 - 财政年份:2000
- 资助金额:
$ 7.25万 - 项目类别:
MAMMALIAN MYOGENESIS SUBSEQUENT TO FETAL DENERVATION
胎儿去神经后的哺乳动物肌生成
- 批准号:
3326824 - 财政年份:1990
- 资助金额:
$ 7.25万 - 项目类别:
MAMMALIAN MYOGENESIS SUBSEQUENT TO FETAL DENERVATION
胎儿去神经后的哺乳动物肌生成
- 批准号:
3326827 - 财政年份:1990
- 资助金额:
$ 7.25万 - 项目类别:
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