MECHANISMS OF PHYSIOLOGICAL RESPONSES TO EXERCISE

运动的生理反应机制

• 批准号: 3334449
• 负责人: KARLMAN WASSERMAN
• 金额: $ 13.6万
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334449
• 关键词: acidosis; anaerobiosis; blood flow measurement; bronchospasm; cardiac output; cardiovascular disorder; cardiovascular pharmacology; cardiovascular stress test; chemoreceptors; computer simulation; electrocardiography; electronic pacemaker; exercise; heart disorder; homeostasis; human subject; hyperoxia; hyperpnea; lung disorder; mathematical model; mechanoreceptors; oxygen consumption; oxygen therapy; pulmonary circulation; respiratory airflow disorder; respiratory airflow measurement; respiratory airway pressure; respiratory airway volume; respiratory gas level

Our objectives are to learn how the cardiorespiratory system normally couples to cell metabolism during exercise and how the coupling is modified by disease states. We aim to: 1) describe the gas exchange responses to exercise and recovery and how the components of the cardiorespiratory system interact to meet the cellular gas exchange needs, 2) demonstrate how disease states disrupt the normal coupling between external and internal respiration during exercise and how this information can be used, diagnostically, 3) develop the clinical applications of the anaerobic threshold, 4) compare metabolic markers of the cell redox state to the continuous, noninvasive, gas exchange techniques for measuring metabolic acidosis, 5) learn the mechanisms by which ventilation is controlled during exercise and how it relates to dyspnea, and 6) use the learned physiologic principles to modify therapy. Using the most advanced measurement systems available and computer technology, breath-by-breath ventilation and gas exchange measurements are made and processed to obtain a quantitative analysis of the dynamic components of gas exchange during exercise and recovery. The kinetics of respiration, circulation and metabolism in response to exercise perturbations, as well as to manipulation of factors affecting gas exchange, provide boundary conditions for the metabolic and ventilatory control mechanisms. In addition, arterial blood analyzed for PO2, PCO2, pH and metabolites which reveal the redox state of the cells define the effectiveness of the ventilatory and circulatory homeostatic mechanisms. The mechanism of the exercise hyperpnea, in man, will be studied within the frame of reference of new clues by which humoral and cardiac changes during exercise link to the ventilatory control mechanism. This project utilizes the disciplines of physiology, biochemistry and computer technology in studies on man and animals to determine the mechanisms which control the dynamics of gas exchange and ventilation during exercise, and to use this knowledge to understand pathophysiology, diagnose and treat patients with exercise limitation and dyspnea.

我们的目标是了解心肺系统如何正常 在运动过程中与细胞代谢的耦合以及如何修改耦合 疾病状态。 我们的目标是：1）描述气体交换反应， 运动和恢复以及心肺功能的组成部分 系统相互作用，以满足细胞气体交换的需要，2）演示如何 疾病状态破坏了外部和内部之间的正常耦合 运动期间的呼吸以及如何使用这些信息， 在诊断上，3）发展厌氧微生物的临床应用 阈值，4）将细胞氧化还原状态的代谢标志物与 用于测量代谢的连续、无创、气体交换技术 酸中毒，5）了解通气控制的机制， 运动及其与呼吸困难的关系，以及6）使用学习的生理学 修改治疗的原则。 使用最先进的测量系统 可用和计算机技术，呼吸呼吸通风和气体 进行并处理交换测量以获得定量的 分析运动过程中气体交换的动态成分， 复苏 呼吸、循环和代谢的动力学 对运动扰动的反应，以及对操纵因素的反应 影响气体交换，为代谢提供边界条件， 控制机制。 此外，分析动脉血中 PO2、PCO2、pH和代谢物，它们揭示了细胞的氧化还原状态 定义排泄和循环稳态的有效性 机制等 运动呼吸过度的机制，在人，将是 在新线索的参考框架内进行研究， 运动时心脏的变化与运动控制机制有关。 该项目利用生理学、生物化学和 计算机技术在人类和动物研究中的应用， 控制气体交换和通风动力学的机制 并利用这些知识来了解病理生理学， 诊断和治疗运动受限和呼吸困难的患者。