ENDOCRINE FUNCTIONS OF THE PLACENTA

我打算学习普罗旺斯的生产和调控。 产生二十烷类化合物(前列环素、血栓素、 羟基二十碳四烯酸(HETE)和白三烯) 正常妊娠和妊娠合并高血压 (子痫前期)。先兆子痫是胎儿的主要原因之一 发育迟缓、早产和产妇死亡。 人胎盘组织将在体外孵育进行研究 生产率和监管因素。二十烷类化合物将是 用放射免疫法测定。具体来说，我将研究：1) 胎盘前列环素和血栓素产生的调节 以及它们失衡增加的原因 血栓素/前列环素降低与子痫前期 胎盘HETES和白三烯的调节及其病因学 先兆子痫的5-和12-脂氧合酶缺陷；3) 环氧合酶之间存在的调节相互作用 (前列腺素和血栓烷)和脂氧合酶(HETE和 花生四烯酸代谢的白三烯产物； 正常和先兆子痫患者白三烯生成率的研究 胎盘。

I plan to study the production and regulation of placentally produced eicosanoids (prostacyclin, thromboxane, hydroxyeicosatetraenoic acids (HETEs) and leukotrienes) in both normal pregnancies and pregnancies complicated by hypertension (preecalmpsia). Preeclampsia is one of the leading causes of fetal growth retardation, premature delivery and maternal death. Human placental tissues will be incubated in vitro to study production rates and regulatory factors. Eicosanoids will be measured by radioimmunoassay. Specifically, I will study: 1) the regulation of placental prostacyclin and thromboxane production, and the etiology of their imbalance of increased thromboxane/decreased prostacyclin in preeclampsia; 2) the regulation of placental HETEs and leukotrienes and the etiology of the 5- and 12-lipoxygenase deficiencies in preeclampsia; 3) the regulatory interactions that exist between the cyclooxygenase (prostaglandins and thromboxane) and lipoxygenase (HETEs and leukotrienes products of arachidonic acid metabolism; 4) the production rates of leukotrienes in normal and preeclamptic placentas.