AROUSAL AND ATTENTION IN HIGH-RISK NEONATES

高危新生儿的唤醒和注意力

• 批准号: 3320894
• 负责人: JUDITH M GARDNER
• 金额: $ 21.95万
• 依托单位: INSTITUTE FOR BASIC RES IN DEV DISABIL
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3320894
• 关键词: arousal; attention; brain injury; cognition disorders; cortisol; developmental nutrition; disease /disorder proneness /risk; evoked potentials; human subject; longitudinal human study; neuropsychology; paired stimuli; perception disorder; performance; premature infant human; stimulus /response

This project investigates the organization of arousal and attention in high-risk neonates suspected of suffering brain insult. Since brain insult is more likely to compromise subcortical and brainstem areas the earlier in development it occurs, and since these regions are more likely to be involved in arousal and attention processes in neonates, we hypothesize the earlier the prematurity when hemorrhage occurs and the more severe the hemorrhage, the less likely will be the ability to change attention as arousal changes. Degree of prematurity should not affect this interaction without corresponding brain insult. Infants will be tested near NICU discharge to establish their visual preferences along a temporal frequency dimension (1, 2, 4, 8 Hz). Preference functions will be obtained by observing the duration of fixation to each member of a pair of simultaneously presented stimuli with all combinations of stimuli balanced. The linear preference function across stimuli, found when a healthy neonate is fed and swaddled, is reversed if the infant is tested before feeding and unswaddled or tested after exposure to prior stimulation. Infants will be divided into 8 groups of 12 (Total N = 96) depending on: (1) the degree of prematurity evidenced by BW and EGA, and (2) the severity of hemorrhage evidenced by ultrasonography and brainstem auditory evoked responses. The normal interaction between arousal conditions in the slopes of the preference functions should be reduced by brain insult, and the more so the earlier the injury occurs in development. The course of recovery as estimated by the reduction in abnormal neurological and vital signs over the course of NICU stay, and the characteristics of the infants neurobehavioral and motor functions will be measured at discharge to obtain additional evidence as to the degree of severity of brain insult and as an alternative, but secondary estimate of resolution of insult. Contrasts will be conducted using these measures to analyze how they are affected by arousal and attention.

这个项目调查了在大脑中唤醒和注意力的组织， 怀疑患有脑损伤的高危新生儿。 自从脑损伤 更有可能损害皮层下和脑干区域， 发展，因为这些地区更有可能是 参与新生儿的唤醒和注意过程，我们假设 出血时早产越早， 出血，越不可能改变注意力， 性唤起的变化 早产的程度不应影响这种相互作用 没有相应的脑损伤。 婴儿将在NICU附近接受检测 放电以沿着时间频率沿着建立他们的视觉偏好 维度（1、2、4、8 Hz）。 偏好函数将通过以下方式获得： 观察对一对中的每个成员的固定的持续时间， 同时呈现的刺激与所有刺激组合 平衡 线性偏好函数的刺激，发现当一个 健康的新生儿被喂养和襁褓，如果婴儿被测试， 在喂食前和暴露于先前的 刺激. 婴儿将被分为8组，每组12例（总N = 96） 取决于：（1）由BW和EGA证明的早产程度，以及 (2)B超和脑干检查显示出血严重程度 听觉诱发反应 唤醒和兴奋之间的正常互动 偏好函数的斜率中的条件应减少 脑损伤，而且损伤发生得越早， 发展 根据减少量估计的恢复过程 在NICU住院期间，神经系统和生命体征异常， 婴儿的神经行为和运动功能的特征将被 在出院时测量，以获得关于 脑损伤的严重程度，并作为替代，但次要的估计 侮辱的解决。 将使用这些措施进行对比， 分析他们是如何受到唤醒和注意力的影响的。