AROUSAL AND ATTENTION IN HIGH RISK NEONATES

拟议中的研究继续研究唤醒的过程， 发展过程中的注意力及其对后来的知觉，认知， 和自动调节系统，在正常婴儿和婴儿的风险， 结果导致CNS损伤。具体目标是确定：1）早期 唤醒和注意的神经基质; 2）唤醒和注意的相互作用 发展的影响;（3）发展的后果 知觉、认知和注意力的觉醒和注意力的转变， 自我调节的发展;和4）验证早期评估 觉醒调节注意力（AMA）作为非典型发育的预测因子， 特别强调自动调节的结果。该设计具有前瞻性， 两个队列的两层纵向研究：336名来自 新生儿重症监护室从出生到34个月，285名儿童先前研究 作为婴儿，并在该项目中从34至60个月进行跟踪。 将在随访年龄（4岁， 新队列为10、16、25和34个月， 现有的队列）。重点是神经生理学测量（视觉和 听觉诱发电位）在新生儿期，行为的措施， 第1年和更高阶的自动调节和AMA过程 执行控制措施，在以后的年龄，为了了解 这些过程在每个时期的前因和后果。结果将 使用多变量、多水平统计程序进行分析，包括GEE 和SEM，如适当。

The proposed research continues a study the process of arousal and attention during development and its influence on later perceptual, cognitive, and autoregulatory systems, in both normal infants and infants at risk for poor outcome due to CNS injury. The specific aims are to determine: 1) the early neural substrates of arousal and attention; 2) the interaction of arousal and attention across development; and 3) the consequences of developmental transitions in arousal and attention for perceptual, cognitive, and autoregulatory development; and to 4) validate an assessment of early arousal-modulated attention (AMA) as a predictor of atypical development, with particular emphasis on autoregulatory outcomes. The design is a prospective, two tiered, longitudinal study of two cohorts: 336 newly recruited infants from the NICU followed from birth to 34 months, and 285 children previously studied as infants, and followed in this project from 34 to 60 months of age. Hypotheses will be tested using a battery of assessments at follow-up ages (4, 10, 16, 25, and 34 months for the new cohort and 34, 42, 51, and 60 months for the existing cohort). Emphasis is on neurophysiologic measures (visual and auditory evoked potentials) in the newborn period, behavioral measures of autoregulatory and AMA processes during the 1st year, and higher order executive control measures at later ages, in order to understand the antecedents and consequences of these processes at each period. Results will be analyzed using multivariate, multilevel statistical procedures including GEE and SEM, as appropriate.