Arousal and Attention Regulation in High Risk Children

高危儿童的唤醒和注意力调节

• 批准号: 7892739
• 负责人: JUDITH M GARDNER
• 金额: $ 1.05万
• 依托单位: INSTITUTE FOR BASIC RES IN DEV DISABIL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2009-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892739
• 关键词: Arousal; Attention; Regulation; Risk; Children

This Program Project builds on knowledge gained from previous funded grants by expanding our hypotheses about the importance of early arousal and attention. It includes Subprojects that add new areas of study and risk populations, as well as extends longitudinally to school-age children. Studies include infants and children from the neonatal period through infancy, and pre-school years, up to early school-age. The design is a prospective longitudinal study of three cohorts: (1) newly recruited infants (n = 330) followed from birth to 34 months; and 2 cohorts of previously recruited infants (2) 275 followed from 34-60 months and (3) 150 children from 60 to 96 months. Adequate development of arousal and attention appears to be a necessary condition underlying normal autoregulatory development, and deficits in autoregulation will have far-reaching effects, producing problems in motor, communication and language, executive function, and cognitive organization. Based on our previous work, the relation between arousal and attention in early infancy is disrupted in systematic and differential ways by risk conditions such as acute CNS injury and neurotoxicity. Similar disruption might be expected by chronic stress in utero and genetic factors. How and when these disruptions take place, and how plasticity affects recovery, have implications for development well beyond the early infancy period, depending on the nature, timing and duration of the influence. Studying arousal, attention, and autoregulation, and how these processes are affected by different pre- and postnatal risk conditions, is fundamental to understanding a broad array of biobehavioral processes and their development, and is of major theoretical and practical importance to multiple disciplines. We propose a Project of programmatic research that is comprised of three Subprojects and two Core units. The Subprojects study development of arousal and attention regulation related to I. Modulation of motor activity, II. Social attention and communication, and III. Executive function. The research is supported by an Administration Core, that includes subject recruitment and maintenance, medical and research data coordination, and statistical analysis, and a Testing Core. Program activities are integrated into a coherent and interactive framework. By examining the findings of individual Subprojects in relation to each other, our major goal is to generate a far richer and more accurate understanding of the mechanisms underlying the development of arousal and attention processes in both typically developing children and in those at risk for poor outcome. This will help us reach our long-term practical goal to elucidate behavioral sequelae of autoregulatory problems in high-risk infants and children.

该计划项目建立在从以前的资助赠款中获得的知识的基础上，通过扩展我们关于早期唤醒和注意力重要性的假设。它包括增加新的研究领域和风险人群的子项目， 并纵向延伸到学龄儿童。研究对象包括新生儿期的婴儿和儿童 从婴儿期到学龄前，一直到学龄早期。该设计是一项前瞻性纵向研究， 队列：（1）新招募的婴儿（n = 330），从出生到34个月随访;和2个队列先前招募的婴儿（n = 330）， 婴儿（2）275例，随访时间为34-60个月;（3）150例，随访时间为60 - 96个月。适当发展 觉醒和注意力似乎是正常自我调节发育的必要条件， 自动调节将产生深远的影响，在运动，沟通和语言，执行问题 功能和认知组织。在前人工作的基础上，我们进一步探讨了早期儿童的唤醒与注意的关系， 婴儿期以系统和不同的方式被诸如急性中枢神经系统损伤和神经毒性的风险条件破坏。 子宫内的慢性压力和遗传因素可能会导致类似的破坏。这些破坏是如何以及何时发生的 发生，以及可塑性如何影响恢复，对婴儿早期以后的发展有影响， 取决于影响的性质、时间和持续时间。研究唤醒，注意力和自动调节，以及如何 这些过程受到不同的产前和产后风险条件的影响， 一系列的生物行为过程及其发展，并具有重大的理论和实践意义，以多个 学科我们提出了一个由三个子项目和两个核心单元组成的方案研究项目。 本子项目研究与I相关的唤醒和注意调节的发展。运动活动的调节，II。 社会关注和沟通，以及三。执行功能。这项研究得到了行政核心的支持， 包括受试者招募和维护、医学和研究数据协调以及统计分析，以及 测试核心。方案活动被纳入一个连贯和互动的框架。通过检查调查结果 我们的主要目标是生成一个更丰富、更准确的 了解两种典型的唤醒和注意过程的发展机制， 发育中的儿童和那些有不良结局风险的儿童。这将有助于我们实现长期的实际目标， 阐明高风险婴儿和儿童的自动调节问题的行为后遗症。

项目成果

Effects of motion and audio-visual redundancy on upright and inverted face and feature preferences in 4-13-month old pre- and full-term NICU graduates.

• DOI: 10.1016/j.infbeh.2020.101439
• 发表时间: 2020-08
• 期刊: Infant behavior & development
• 影响因子: 2.1
• 作者: Kittler PM;Kim SY;Flory MJ;Phan HTT;Karmel BZ;Gardner JM
• 通讯作者: Gardner JM

Early social referencing predicts object mastery motivation in infancy: Social antecedents of object mastery motivation.

早期社会参考预测婴儿期的物体掌握动机：物体掌握动机的社会前因。

• DOI: 10.1111/infa.12557
• 发表时间: 2023
• 期刊: Infancy : the official journal of the International Society on Infant Studies
• 作者: Yanchik,Amelia;Gardner,JudithM;Karmel,BernardZ;Vietze,Peter
• 通讯作者: Vietze,Peter

Neonatal brainstem function and 4-month arousal-modulated attention are jointly associated with autism.

• DOI: 10.1002/aur.1259
• 发表时间: 2013-02
• 期刊: AUTISM RESEARCH
• 影响因子: 4.7
• 作者: Cohen, Ira L.;Gardner, Judith M.;Karmel, Bernard Z.;Phan, Ha T. T.;Kittler, Phyllis;Gomez, Tina Rovito;Gonzalez, Maripaz G.;Lennon, Elizabeth M.;Parab, Santosh;Barone, Anthony
• 通讯作者: Barone, Anthony