METABOLISM IN THE NONHUMAN PRIMATE AND OVINE FETUS

这项研究继续研究能量代谢的性质 胎儿。一种慢性胎羊制剂和一种慢性非人类灵长类 模型，即胎儿狒狒，正在被用来扩展之前的研究 定量能量代谢。底物的吸收和生产 通过利用适当放置的动脉对胚胎动物进行评估 和静脉导管，用于采集动静脉代谢差异， 放射性前体示踪技术和胎儿血流的测量 和特定器官的血液流动。我们计划研究胎儿的能力 控制糖异生、糖生成和糖原分解 充满敌意的母体新陈代谢环境，尤其注重内源性 激素或底物介导的控制机制。此外, 荷尔蒙控制机制的药理学探针将在 怀孕动物体内的稳定状态。这些研究是 与糖尿病婴儿的临床问题直接相关 母亲，可能接触到急性低血糖，或急性和慢性 高血糖，以及卡路里缺乏者的婴儿， 营养不良的母亲。

The study continues investigations into the nature of energy metabolism in the fetus. A chronic fetal lamb preparation and a chronic nonhuman primate model, the fetal baboon, are being used to extend previous studies of quantitative energy metabolism. Substrate uptake and production by the fetal animals is being evaluated by utilizing appropriately placed arterial and venous catheters for sampling arteriovenous metabolic differences, radioactive precursor tracer techniques, and measures of fetal blood flow and specific organ blood flows. We plan to study the capacity of the fetus to control gluconeogenesis, glycogenesis, and glycogenolysis in the face of a hostile maternal metabolic milieu, focusing particularly on endogenous hormonal or substrate mediated control mechanisms. In addition, pharmacologic probes of hormonal control mechanisms will be employed during steady state conditions in the pregnant animal. These studies are immediately relevant to the clinical problems of the infant of the diabetic mother, who may be exposed to acute hypoglycemia, or acute and chronic hyperglycemia, and to the infant of the calorically deprived, undernourished mother.